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Pharmacologic treatment of rheumatoid arthritis

Cho SK, Bae SC

Rheumatoid arthritis (RA) is a systemic inflammatory disease that affects the joints. This chronic inflammatory condition causes joint destruction and functional disability, and reduces the quality of life of patients....
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Advances in Treatment for Polycythemia Vera and Essential Thrombocythemia

Kim SY

Although there have been substantial advances in confirming diagnoses and defining the molecular characteristics of polycythemia vera (PV) and essential thrombocythemia (ET), treatments for these conditions remain elementary. The main...
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Current concepts in the management of rheumatoid arthritis

Tanaka Y

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction that causes significant morbidity and mortality. However, the combined use of methotrexate, a synthetic disease-modifying antirheumatic...
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Current and Emerging Biologics for Ulcerative Colitis

Park SC, Jeen YT

Conventional medical treatment for ulcerative colitis can have limited efficacy or severe adverse reactions requiring additional treatment or colectomy. Hence, different biological agents that target specific immunological pathways are being...
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Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials

Song GG, Bae SC, Lee YH

BACKGROUND/AIMS: The aim of this study was to assess the efficacy and safety of tofacitinib (5 and 10 mg twice daily) in patients with active rheumatoid arthritis (RA). METHODS: A systematic...
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Anti-inflammatory activity of compounds isolated from Astragalus sinicus L. in cytokine-induced keratinocytes and skin

Kim BH, Oh I, Kim JH, Jeon JE, Jeon B, Shin J, Kim TY

Inflammation is a part of the complex biological responses of a tissue to injury that protect the organ by removing injurious stimuli and initiating the healing process, and is considered...
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The efficacy of SPA0355 in protecting beta cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes

Bae UJ, Song MY, Jang HY, Gim HJ, Ryu JH, Lee SM, Jeon R, Park BH

  • KMID: 2154270
  • Exp Mol Med.
  • 2013 Nov;45(11):e51.
Cytokines activate several inflammatory signals that mediate beta-cell destruction. We recently determined that SPA0355 is a strong anti-inflammatory compound, thus reporting its efficacy in protecting beta cells from various insults....
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The Efficacy and Safety of a Tofacitinib in the Treatment of Active Ulcerative Colitis

Seo GS

No abstract available.
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An Association Study of Polymorphisms in JAK3 Gene with Lung Cancer in the Korean Population

Yoo W, Jung HY, Lim S, Sung JS, Park KH, Ryu JS, Shin SW, Kim JS, Seo JH, Kim YH

  • KMID: 2167536
  • Cancer Res Treat.
  • 2011 Jun;43(2):108-116.
PURPOSE: The genetic alteration of the janus kinases (JAKs), non-receptor tyrosine kinase, is related to the development of human cancers. However, little is known about how the sequence variation of...
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Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression

Wang Z, Jin H, Xu R, Mei Q, Fan D

Triptolide, a diterpenoid triepoxide from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f., is a potential treatment for autoimmune diseases as well a possible anti-tumor agent. It inhibits proliferation...
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Mutational Analysis of JAK1 Exons 10 and 13 in Non-small Cell Lung Cancers

Oh JE, Yoon HK, Woo IS, Kim SJ, Yoo NJ, Lee SH

PURPOSE : JAK kinases play important roles not only in normal cellular processes, but they are also important in tumor development. A recent study identified two somatic mutations of JAK1...
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Essential roles for ID-1 motif of interleukin-4 receptor alpha chain in interleukin-4 signaling

Youn J, Lee KH, Hwang WY, Paik DJ, Chung HS

  • KMID: 2285854
  • J Asthma Allergy Clin Immunol.
  • 2003 Jun;23(2):372-384.
BACKGROUND: Interleukin (IL)-4 is a pleiotropic cytokine that plays an important role in the pathogenesis of the allergic inflammation and asthma. Upon IL-4 receptor (IL-4R) engagement, a variety of signaling...
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