- Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice
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Oh YB, Ahn M, Lee SM, Koh HW, Lee SH, Kim SH, Park BH
- KMID: 2154242
- Exp Mol Med.
- 2013 May;45(5):e23.
Recent studies have documented that Janus-activated kinase (JAK)-signal transducer and activator of transcription (STAT) pathway can modulate the apoptotic program in a myocardial ischemia/reperfusion (I/R) model. To date, however, limited... -
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- Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling
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Kim BH, Min YS, Choi JS, Baeg GH, Kim Y, Shin JW, Kim TY, Ye SK
- KMID: 1009971
- Exp Mol Med.
- 2011 May;43(5):313-321.
- doi: 10.3858/emm.2011.43.5.035
Persistently activated JAK/STAT3 signaling pathway plays a pivotal role in various human cancers including major carcinomas and hematologic tumors, and is implicated in cancer cell survival and proliferation. Therefore, inhibition... -
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