- MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells
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Kang YJ, Kwon YH, Jang JY, Lee JH, Lee S, Park Y, Moon HR, Chung HY, Kim ND
- KMID: 2537583
- Biomol Ther.
- 2023 Jan;31(1):73-81.
- doi: 10.4062/biomolther.2022.044
Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA... -
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- Efonidipine Inhibits JNK and NF-κB Pathway to Attenuate Inflammation and Cell Migration Induced by Lipopolysaccharide in Microglial Cells
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Nguyen NM, Duong MTH, Nguyen PL, Bui BP, Ahn HC, Cho J
- KMID: 2532878
- Biomol Ther.
- 2022 Sep;30(5):455-464.
- doi: 10.4062/biomolther.2022.076
Efonidipine, a calcium channel blocker, is widely used for the treatment of hypertension and cardiovascular diseases. In our preliminary study using structure-based virtual screening, efonidipine was identified as a potential... -
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- Sec-O-glucosylhamaudol mitigates inflammatory processes and autophagy via p38/JNK MAPK signaling in a rat neuropathic pain model
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Oh SH, Kim SW, Kim DJ, Kim SH, Lim KJ, Lee K, Jung KT
- KMID: 2520748
- Korean J Pain.
- 2021 Oct;34(4):405-416.
- doi: 10.3344/kjp.2021.34.4.405
Background: This study investigated the effect of intrathecal Sec-O-glucosylhamaudol (SOG) on the p38/c-Jun N-terminal kinase (JNK) signaling pathways, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-related inflammatory responses, and autophagy... -
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- Effect and Mechanism Study of Sodium Houttuyfonate on Ventilator-Induced Lung Injury by Inhibiting ROS and Inflammation
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Liu Y, Tang G, Li J
- KMID: 2516087
- Yonsei Med J.
- 2021 Jun;62(6):545-554.
- doi: 10.3349/ymj.2021.62.6.545
Purpose: Ventilator-induced lung injury (VILI) is a serious complication of mechanical ventilation (MV) that increases morbidity and mortality of patients receiving ventilator treatment. This study aimed to reveal the molecular... -
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- Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells
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Na YJ, Yu ES, Kim DS, Lee DH, Oh SC, Choi CW
- KMID: 2513827
- Korean J Intern Med.
- 2021 Mar;36(Suppl 1):S196-S206.
- doi: 10.3904/kjim.2019.336
Background/Aims: Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years. In addition, a considerable number of... -
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- Poncirin Inhibits Osteoclast Differentiation and Bone Loss through Down-Regulation of NFATc1 In Vitro and In Vivo
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Chun KH, Jin HC, Kang KS, Chang TS, Hwang GS
- KMID: 2503473
- Biomol Ther.
- 2020 Jul;28(4):337-343.
- doi: 10.4062/biomolther.2018.216
Activation of osteoclast and inactivation of osteoblast result in loss of bone mass with bone resorption, leading to the pathological progression of osteoporosis. The receptor activator of NF-κB ligand (RANKL)... -
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- Inhibitory Effect of Probenecid on Osteoclast Formation via JNK, ROS and COX-2
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Cheng MH, Kim SJ
- KMID: 2507801
- Biomol Ther.
- 2020 Jan;28(1):104-109.
- doi: 10.4062/biomolther.2019.047
Probenecid is a representative drug used in the treatment of gout. A recent study showed that probenecid effectively inhibits oxidative stress in neural cells. In the present study, we investigated... -
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- Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation in cultured human keratinocytes
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Bae IH, Lee SH, Oh S, Choi H, Marinho PA, Yoo JW, Ko JY, Lee ES, Lee TR, Lee CS, Kim DY
- KMID: 2438085
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):113-120.
- doi: 10.4196/kjpp.2019.23.2.113
Mannosylerythritol lipids (MELs) are glycolipids and have several pharmacological efficacies. MELs also show skin-moisturizing efficacy through a yet-unknown underlying mechanism. Aquaporin-3 (AQP3) is a membrane protein that contributes to the... -
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- Acebutolol, a Cardioselective Beta Blocker, Promotes Glucose Uptake in Diabetic Model Cells by Inhibiting JNK-JIP1 Interaction
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Li Y, Jung NY, Yoo JC, Kim Y, Yi GS
- KMID: 2421723
- Biomol Ther.
- 2018 Sep;26(5):458-463.
- doi: 10.4062/biomolther.2017.123
The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development... -
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- Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways
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Lee KJ, Jang YO, Cha SK, Kim MY, Park KS, Eom YW, Baik SK
- KMID: 2417312
- Gut Liver.
- 2018 Jul;12(4):449-456.
- doi: 10.5009/gnl17443
BACKGROUND/AIMS: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the β-Klotho and FGF21 pathway... -
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- YJI-7 Suppresses ROS Production and Expression of Inflammatory Mediators via Modulation of p38MAPK and JNK Signaling in RAW 264.7 Macrophages
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Oh HJ, Magar TB, Pun NT, Lee Y, Kim EH, Lee ES, Park PH
- KMID: 2429059
- Biomol Ther.
- 2018 Mar;26(2):191-200.
- doi: 10.4062/biomolther.2016.276
Chalcone, (2E)-1,3-Diphenylprop-2-en-1-one, and its synthetic derivatives are known to possess anti-oxidative and anti-inflammatory properties. In the present study, we prepared a novel synthetic chalcone compound, (E)-1-(4-hydroxyphenyl)-3-(2-(trifluoromethoxy)phenyl)prop-2-en-1-one name (YJI-7), and investigated... -
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- Quercetin-3-O-β-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells
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Park JY, Lim MS, Kim SI, Lee HJ, Kim SS, Kwon YS, Chun W
- KMID: 2374615
- Biomol Ther.
- 2016 Nov;24(6):610-615.
- doi: 10.4062/biomolther.2016.026
Quercetin, a flavonol, has been reported to exhibit a wide range of biological properties including anti-oxidant and anti-inflammatory activities. However, pharmacological properties of quercetin-3-O-β-D-glucuronide (QG), a glycoside derivative of quercetin,... -
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- Shikonin Induces Apoptotic Cell Death via Regulation of p53 and Nrf2 in AGS Human Stomach Carcinoma Cells
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Ko H, Kim SJ, Shim SH, Chang H, Ha CH
- KMID: 2351674
- Biomol Ther.
- 2016 Sep;24(5):501-509.
- doi: 10.4062/biomolther.2016.008
Shikonin, which derives from Lithospermum erythrorhizon, has been traditionally used against a variety of diseases, including cancer, in Eastern Asia. Here we determined that shikonin inhibits proliferation of gastric cancer... -
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- Glucose Levels in Culture Medium Determine Cell Death Mode in MPP+-treated Dopaminergic Neuronal Cells
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Yoon SY, Oh YJ
- KMID: 2165555
- Exp Neurobiol.
- 2015 Sep;24(3):197-205.
- doi: 10.5607/en.2015.24.3.197
We previously demonstrated that 1-methyl-4-phenylpyridinium (MPP+) causes caspase-independent, non-apoptotic death of dopaminergic (DA) neuronal cells. Here, we specifically examined whether change of glucose concentration in culture medium may play a... -
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- Cardamonin Suppresses TGF-beta1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression
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Kim EJ, Kim HJ, Park MK, Kang GJ, Byun HJ, Lee H, Lee CH
- KMID: 2380347
- Biomol Ther.
- 2015 Mar;23(2):141-148.
- doi: 10.4062/biomolther.2014.117
Epithelial mesenchymal transition (EMT) is the first step in metastasis and implicated in the phenotype of cancer stem cells. Therefore, understanding and controlling EMT, are essential to the prevention and... -
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- N-(p-Coumaryol)-Tryptamine Suppresses the Activation of JNK/c-Jun Signaling Pathway in LPS-Challenged RAW264.7 Cells
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Vo VA, Lee JW, Park JH, Kwon JH, Lee HJ, Kim SS, Kwon YS, Chun W
- KMID: 2170637
- Biomol Ther.
- 2014 May;22(3):200-206.
N-(p-Coumaryol) tryptamine (CT), a phenolic amide, has been reported to exhibit anti-oxidant and anti-inflammatory activities. However, the underlying mechanism by which CT exerts its pharmacological properties has not been clearly... -
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- Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity
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Xia A, Xue Z, Wang W, Zhang T, Wei T, Sha X, Ding Y, Zhou W
- KMID: 2285493
- Korean J Physiol Pharmacol.
- 2014 Feb;18(1):67-72.
- doi: 10.4196/kjpp.2014.18.1.67
To investigate the alteration of c-Jun N-terminal kinase (JNK) activity after myocardial ischemia reperfusion injury (MIRI) and further explore the effect of naloxone postconditioning on MIRI. Forty male Sprague Dawley... -
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- Kalopanaxsaponin A Exerts Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated Microglia via Inhibition of JNK and NF-kappaB/AP-1 Pathways
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Jeong YH, Hyun JW, Kim Van Le T, Kim DH, Kim HS
- KMID: 2048302
- Biomol Ther.
- 2013 Sep;21(5):332-337.
Microglial activation plays an important role in the development and progression of various neurological disorders such as cerebral ischemia, multiple sclerosis, and Alzheimer's disease. Thus, controlling microglial activation can serve... -
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- Valproic Acid Regulates alpha-Synuclein Expression through JNK Pathway in Rat Primary Astrocytes
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Kim JN, Kim MK, Cho KS, Choi CS, Park SH, Yang SI, Joo SH, Park JH, Bahn G, Shin CY, Lee HJ, Han SH, Kwon KJ
- KMID: 1502491
- Biomol Ther.
- 2013 May;21(3):222-228.
Although the role of alpha-synuclein aggregation on Parkinson's disease is relatively well known, the physiological role and the regulatory mechanism governing the expression of alpha-synuclein are unclear yet. We recently... -
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- Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of NF-kappaB and Phosphorylation of JNK in RAW 264.7 Macrophage Cells
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Lee JW, Kim NH, Kim JY, Park JH, Shin SY, Kwon YS, Lee HJ, Kim SS, Chun W
- KMID: 1502490
- Biomol Ther.
- 2013 May;21(3):216-221.
Aromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties. However, the underlying mechanism by which aromadendrin exerts its biological... -
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