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Protein kinase A mediates microglial activation induced by plasminogen and gangliosides

Min KJ, Yang MS, Jou I, Joe EH

  • KMID: 1123767
  • Exp Mol Med.
  • 2004 Oct;36(5):461-467.
In the injured brain, microglia is known to be activated and produce proinflammatory mediators such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS). We investigated...
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Protein kinase C micron plays an essential role in hypertonicity-induced heat shock protein 70 expression

Lim YS, Lee JS, Huang TQ, Seo JS

Heat shock protein 70 (HSP70), which evidences important functions as a molecular chaperone and anti-apoptotic molecule, is substantially induced in cells exposed to a variety of stresses, including hypertonic stress,...
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