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Effects of N-Acetylcysteine on Nicotinamide Dinucleotide Phosphate Oxidase Activation and Antioxidant Status in Heart, Lung, Liver and Kidney in Streptozotocin-Induced Diabetic Rats

Lei S, Liu Y, Liu H, Yu H, Wang H, Xia Z

PURPOSE: Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress plays a key role in the pathogenesis of diabetic complications. Nicotinamide dinucleotide phosphate (NADPH) oxidase is one of...
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Oxidatvive Stress in Rat Model of Preeclampsia and Clinical Correlates

Chang YJ, Lee WK, Kim HG

  • KMID: 2285336
  • Korean J Physiol Pharmacol.
  • 2007 Jun;11(3):129-133.
There are growing evidences suggesting a pivotal role of oxidative stress in the pathophysiology of preeclampsia. We investigated oxidative stress in the rat model of preeclampsia, and in clinical cases....
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The Effect of Repetitive Hypoxia on Production of Lipid Peroxidation in Newborn Rat Brain

Kim IS, Suk HJ, Park JS, Park MS, Park MS

  • KMID: 2144561
  • J Korean Soc Neonatol.
  • 2003 Nov;10(2):235-240.
PURPOSE: Among many pathophysiologic mechanisms of hypoxic-ischemic brain injury, reactive oxygen species (ROS) cause or contribute to brain damage relates to their ability to attack the fatty acid moiety of...
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Umbilical Cord Arterial Concentrations of Isoprostane(8-iso-PGF2alpha) in Newborn Infants

Lee KS, Ji YH, Chang YP

  • KMID: 1607029
  • J Korean Pediatr Soc.
  • 2003 Sep;46(9):865-870.
PURPOSE: We measured the umbilical cord arterial concentrations of isoprostane(8-iso-PGF2alpha) and intended to decide whether the umbilical cord arterial concentrations of isoprostane could be used as a useful parameter for...
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Efficacy of midtrimester amniotic fluid 8-isoprostane measurement in the prediction of severe preeclampsia

Kim SR, Lee PR, Koo BS, Kim JS, Chung JY, Won HS, Kim A

  • KMID: 2129002
  • Korean J Obstet Gynecol.
  • 2002 Oct;45(10):1785-1793.
OBJECTIVE: The objective of this study is to investigate whether the amniotic fluid 8-isoprostane levels at the time of genetic amniocentesis is a marker for severe preeclampsia. METHODS: A case-control...
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Changes in the Levels of Eicosanoids and Isoprostane (8-iso-PGF2alpha) in the Newborn Rat Brain after Hypoxic-Ischemic Injury

Lee HY, Jung MK, Kim JA, Chang YP, Hyun KS, Kim HG, Hwang TJ

  • KMID: 2099016
  • J Korean Soc Neonatol.
  • 2000 May;7(1):45-53.
PURPOSE: The changes in the levels of eicosanoids and isoprostane (8-iso-PGF2alpha) were investigated in brain tissue of 7 day-old rats after hypoxic-ischemic (HI) injury. METHODS: The 7 day-old newborn rats...
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Simultaneous HPLC analysis of arachidonic acid metabolites in biological samples with simple solid phase extraction

Kim HG, Huh YN, Park KS

  • KMID: 2071837
  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):779-786.
A reversed-phase high-performance liquid chromatography (RP-HPLC) has been developed to analyze the metabolites of arachidonic acid based on the specificities of ultraviolet absorption of these various metabolites and is sensitive to the nanogram...
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