- Molecular characteristics of the inhibition of human neutrophil elastase by nonsteroidal antiinflammatory drugs
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Kang K, Bae SJ, Kim WM, Lee DH, Cho US, Lee MS, Lee MH, Nam SI, Kuettner K, Schwartz D
- KMID: 755079
- Exp Mol Med.
- 2000 Sep;32(3):146-154.
Nonsteroidal antiinflammatory drugs(NSAIDs) are known as clinically effective agents for treatment of inflammatory diseases. Inhibition of cyclooxygenase has been thought to be a major facet of the pharmacological mechanism of... -
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- Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes
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Choi YA, Lee DJ, Lim HK, Jeong JH, Sonn JK, Kang SS, Baek SH
- KMID: 1097104
- Exp Mol Med.
- 2004 Jun;36(3):226-232.
IL-1beta is known promote cyclooxygenase-2 (COX- 2) and matrix metalloproteinase-2 (MMP-2) expression. This study focuses on the characterization of the signaling cascade associated with IL-1beta-induced matrix metalloproteinase-2 (MMP- 2) regulation... -
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