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Diverse Ischemic Postconditioning Protocols Affect the Infarction Size in Focal Ischemic Stroke

Lee JS, Song DJ, Hong JH, Kim TS, Joo SP

OBJECTIVE: Ischemic postconditioning (IPostC), consisted of transient brain ischemia/reperfusion cycles, is considered to have neuroprotective effect. However, there is no best single protocol of IPostC, because varied factors like species...
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Cardioprotective Effect of the SDF-1α/CXCR4 Axis in Ischemic Postconditioning in Isolated Rat Hearts

Kim JS, Jang Y, Kim JH, Park YH, Hwang SA, Kim J, Lee SR, Xu Z, Ban C, Ahn K, Chun KJ

BACKGROUND AND OBJECTIVES: Information about the role of the stromal cell-derived factor-1α (SDF-1α)/chemokine receptor type 4 (CXCR4) axis in ischemic postconditioning (IPOC) is currently limited. We hypothesized that the SDF-1α/CXCR4...
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Effect of isoflurane post-treatment on tPA-exaggerated brain injury in a rat ischemic stroke model

Kim EJ, Kim SY, Lee JH, Kim JM, Kim JS, Byun JI, Koo BN

BACKGROUND: Intravenous tissue-type plasminogen activator (tPA) is recognized as the standard treatment for ischemic stroke. However, its narrow therapeutic window and association with an increased risk of intracranial hemorrhage have...
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Protective effect of ischemic postconditioning against hepatic ischemic reperfusion injury in rat liver

Yoon SY, Kim CY, Han HJ, Lee KO, Song TJ

PURPOSE: The efficiency of ischemic postconditioning (IPC) was evaluated in a rat model of ischemic liver. Concentration of survivin of liver tissue correlated with the degree of antiapoptosis, so survivin...
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Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes

Kim JM, Jang YH, Kim J

During the past few decades, a large number of animal studies demonstrated that commonly used opioids could provide cardioprotection against ischemia-reperfusion (I/R) injury. Opioid-induced preconditioning or postconditioning mimics ischemic preconditioning...
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