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Interferon-gamma release assay has poor diagnostic accuracy in differentiating intestinal tuberculosis from Crohn’s disease in tuberculosis endemic areas

Sachdeva K, Kumar P, Kante B, Vuyyuru SK, Mohta S, Ranjan MK, Singh MK, Verma M, Makharia G, Kedia S, Ahuja V

Background/Aims: Intestinal tuberculosis (ITB) and Crohn’s disease (CD) frequently present with a diagnostic dilemma because of similar presentation. Interferon-gamma release assay (IGRA) has been used in differentiating ITB from CD,...
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Addition of computed tomography chest increases the diagnosis rate in patients with suspected intestinal tuberculosis

Kedia S, Sharma R, Vuyyuru SK, Madhu D, Sahu P, Kante B, Das P, Goyal A, Madan K, Makharia G, Ahuja V

Background/Aims: Intestinal tuberculosis (ITB) is difficult to diagnose due to poor sensitivity of definitive diagnostic tests. ITB may be associated with concomitant pulmonary tuberculosis (PTB) which may remain undetected on...
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Value of Fecal Calprotectin Measurement During the Initial Period of Therapeutic Anti-Tubercular Trial

Jo HH, Kim EY, Jung JT, Kwon JG, Kim ES, Lee HS, Lee YJ, Kim KO, Jang BI, on behalf of the Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)

Background/Aims: The diagnosis of intestinal tuberculosis (Itbc) is often challenging. Therapeutic anti-tubercular trial (TATT) is sometimes used for the diagnosis of Itbc. We aimed to evaluate the changing pattern of...
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Gut Microbiome in Probable Intestinal Tuberculosis and Changes following Anti-Tuberculosis Treatment

Purpose: Information on the gut microbiome in patients with intestinal tuberculosis (ITB) and changes therein following anti-tuberculosis treatment (ATT) is lacking. We aimed to elucidate differences in stool microbiome between...
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Differentiating between Intestinal Tuberculosis and Crohn’s Disease May Be Complicated by Multidrug-resistant Mycobacterium tuberculosis

Hong SW, Park SH, Ye BD, Yang SK

Differentiating between intestinal tuberculosis (ITB) and Crohn’s disease (CD) remains a challenge for gastroenterologists. In Asia, where the prevalence of tuberculosis is relatively high and the incidence of CD is...
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Prospective validation of CD4+CD25+FOXP3+ T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn’s disease

Rampal R, Kedia S, Wari MN, Madhu D, Singh AK, Tiwari V, Mouli VP, Mohta S, Makharia G, Ahuja V

Background/Aims: Crohn’s disease (CD) and intestinal tuberculosis (ITB) remain “difficult-to-differentiate” diseases. We have previously documented peripheral blood frequency of CD4+CD25+FOXP3+ T-regulatory cells (Treg) as a biomarker to differentiate CD and...
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Intestinal tuberculosis or Crohn’s disease: a review of the diagnostic models designed to differentiate between these two gastrointestinal diseases

Limsrivilai J, Pausawasdi N

Differentiating Crohn’s disease (CD) from intestinal tuberculosis (ITB) is a diagnostic dilemma, particularly in regions where ITB is prevalent and CD incidence is increasing, because both diseases can present quite...
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Accuracy of computed tomographic features in differentiating intestinal tuberculosis from Crohn's disease: a systematic review with meta-analysis

Kedia S, Sharma R, Sreenivas , Madhusudhan KS, Sharma V, Bopanna S, Pratap Mouli V, Dhingra R, Yadav DP, Makharia G, Ahuja V

Abdominal computed tomography (CT) can noninvasively image the entire gastrointestinal tract and assess extraintestinal features that are important in differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB). The present meta-analysis...
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Differences in Clinical Manifestations according to the Positivity of Interferon-γ Assay in Patients with Intestinal Tuberculosis

Jung HJ, Kim YH, Kim YS, Jeong SY, Park SW, Seo JY, Jung H, Im JP, Kim JW, Hong SN, Lee KL

Intestinal tuberculosis (ITB) remains prevalent in Asia. An interferon-γ assay (QuantiFERON-TB gold test [QFT]) is considered to be an effective supplementary tool for diagnosing ITB. We retrospectively analyzed the clinical...
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A Case of Intestinal Tuberculosis with Perianal Fistula Diagnosed after 30 Years

Cheon JH, Moon W, Park SJ, Park MI, Kim SE, Choi YJ, Kim JB, Kwon HJ

Tuberculosis can occur anywhere in the gastrointestinal tract. However, anorectal tuberculosis has rarely been reported. A 46-years-old male presented with abdominal pain and perianal discharge of 30 years' duration. The...
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Computed Tomography Enterography for Evaluation of Inflammatory Bowel Disease

Park MJ, Lim JS

  • KMID: 2425252
  • Clin Endosc.
  • 2013 Jul;46(4):327-366.
Computed tomography enterography (CTE) has become a main modality for the evaluation of inflammatory bowel disease (IBD). It simultaneously offers visualization of the small bowel and extraintestinal status, which is...
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Gastric Cancer and Concomitant Gastric Tuberculosis: A Case Report

Kang HJ, Lee YS, Jang YJ, Mok YJ

  • KMID: 2372458
  • J Gastric Cancer.
  • 2012 Dec;12(4):254-257.
Gastric tuberculosis is rare even in the endemic areas of tuberculosis, and can mimic neoplasm by causing elevation of the mucosa with or without ulceration. Here, we report a case...
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A Survey of Actual Clinical Application Patterns in Korean Diagnostic Guidelines for Inflammatory Bowel Disease

Park SJ, Cheon JH, Ye BD, Choi CH, Kim YS, Kim YH, Kim JS, Jeen YT, Park YS, Han DS, Yang SK, Kim WH

BACKGROUND/AIMS: The aim of this study was to analyze the actual application patterns of how Korean diagnostic guidelines for inflammatory bowel disease (IBD) were applied in clinical practice. METHODS: Questionnaires regarding...
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Cecal Fecaloma Due to Intestinal Tuberculosis: Endoscopic Treatment

Kim SM, Ryu KH, Kim YS, Lee TH, Im EH, Huh KC, Choi YW, Kang YW

Colorectal fecaloma is a mass of accumulated feces that is much harder in consistency than a fecal impactation. The rectosigmoid area is the common site for fecalomas and the cecum...
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Clinical Features of Intestinal Tuberculosis in Recent Ten Years (2001-2010)

Cho JY, Kim YS, Park WW, Chuan TP, Kim HT, Lee SR, Lee JH, Moon JS

BACKGROUND/AIMS: Intestinal tuberculosis (ITB) evades early diagnosis due to non-specific clinical manifestations and difficulties in confirming the disease process. In the current study, we determined the diagnostic appearance and clinical...
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The Usefulness of In Vitro Interferon-gamma Assay for Differential Diagnosis between Intestinal Tuberculosis and Crohn's Disease

Lee JN, Ryu DY, Park SH, You HS, Lee BE, Kim DU, Kim TO, Heo J, Kim GH, Song GA, Kim S, Park DY

BACKGROUND/AIMS: It is difficult to clinically and endoscopically differentiate intestinal tuberculosis (ITB) and Crohn's disease (CD). The aim of this study was to evaluate the usefulness of in vitro interferon-gamma...
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A Case of Pseudomembranous Colitis Associated with Rifampicin Therapy in a Patient with Rectal Cancer and Gastrointestinal Tuberculosis

Choi YJ, Kim HG, Choi YA, Joo WC, Son DW, Kim CH, Shin YW, Kim YS

  • KMID: 783128
  • Korean J Gastroenterol.
  • 2009 Jan;53(1):53-56.
Pseudomembranous colitis (PMC) is known to be associated with the administration of antibiotics which alter normal gastrointestinal flora and allow overgrowth of Clostridium difficile. Most cases of rifampicin-induced PMC are...
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The Changes in Incidence of Crohn's Disease and Intestinal Tuberculosis in Korea

Chung KM, Kim HS, Park SY, Lim SR, Ryang DY, Jeong HK, Lee WS, Park CH, Lee JH, Choi SK, Rew JS

  • KMID: 783111
  • Korean J Gastroenterol.
  • 2008 Dec;52(6):351-358.
BACKGROUND/AIMS: The incidence of Crohn's disease (CD) has been steadily increasing in Korea due to westernized life style and widely used imaging studies such as colonoscopy. There were few studies...
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A Case of Colon Cancer Coexisting with Colonic Tuberculosis

Cha JM, Lee JI, Choe JW, Joo KR, Jung SW, Shin HP, Hew WY, Lee SH

  • KMID: 2084552
  • Korean J Gastrointest Endosc.
  • 2008 Nov;37(5):369-373.
Patients with chronic inflammatory bowel disease have a potential risk for developing colorectal cancer. Simultaneous occurrence of tuberculosis and colon cancer at the same segment of the colon has been...
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A Case of Synchronous Intestinal Tuberculosis Involving the Stomach and Colon

Kim JH, Jeon YC, Kim TY, Eun CS, Sohn JH, Han DS, Jang JJ, Park YW

  • KMID: 783105
  • Korean J Gastroenterol.
  • 2008 Nov;52(5):320-324.
Intestinal tuberculosis is a common disease of extrapulmonary tuberculosis and should be differentiated from the inflammatory bowel diseases and malignancy such as Crohn's disease, ulcerative colitis, amebic colitis, and colon...
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