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Leaky Gut Syndrome

Kim KN, Kim KM

Increased intestinal permeability, termed leaky gut syndrome (LGS), plays an important role in health and disease. LGS creates gaps in the intestinal walls that allow harmful bacteria and toxic substances...
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The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model

Kwak DS, Lee OY, Lee KN, Jun DW, Lee HL, Yoon BC, Choi HS

BACKGROUND/AIMS: DA-6034 has anti-inflammatory activities and exhibits cytoprotective effects in acute gastric injury models. However, explanations for the protective effects of DA-6034 on intestinal permeability are limited. This study sought...
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Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-alpha related mechanism

Tian S, Guo R, Wei S, Kong Y, Wei X, Wang W, Shi X, Jiang H

Present study aimed to investigate the eff ect of curcumin-pretreatment on intestinal I/R injury and on intestinal mucosa barrier. Thirty Wistar rats were randomly divided into: sham, I/R, and curcumin...
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Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder

Pusponegoro HD, Ismael S, Sastroasmoro S, Firmansyah A, Vandenplas Y

PURPOSE: Various gastrointestinal factors may contribute to maladaptive behavior in children with autism spectrum disorders (ASD). To determine the association between maladaptive behavior in children with ASD and gastrointestinal symptoms...
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Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis

Yuan B, Zhou S, Lu Y, Liu J, Jin X, Wan H, Wang F

BACKGROUND/AIMS: This animal study aimed to define the underlying cellular mechanisms of intestinal barrier dysfunction. METHODS: Rats were fed 4% with dextran sodium sulfate (DSS) to induce experimental colitis. We analyzed...
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Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases

Lee SH

Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of macromolecules. The TJ is multi-protein complex that forms a selective permeable seal between adjacent epithelial cells and demarcates...
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The Effect of Intestinal Permeability and Endotoxemia on the Prognosis of Acute Pancreatitis

Koh YY, Jeon WK, Cho YK, Kim HJ, Chung WG, Chon CU, Oh TY, Shin JH

  • KMID: 2167424
  • Gut Liver.
  • 2012 Oct;6(4):505-511.
BACKGROUND/AIMS: Early intestinal mucosal damage plays an important role in severe acute pancreatitis (AP). Previous studies have shown that intestinal permeability (IP), serum endotoxin and cytokines contribute to the early...
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Complement and Integrative Approach in Gut Health and Immunologic Disease

Jeon WK

The intestine is an organ involved with absorbing, processing, and transporting food into the body. However, if one were to assess the immunological portion of the intestine and compare it...
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The Relationship between Small-Intestinal Bacterial Overgrowth and Intestinal Permeability in Patients with Irritable Bowel Syndrome

Park JH, Park DI, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Won KH, Park SM

  • KMID: 2284059
  • Gut Liver.
  • 2009 Sep;3(3):174-179.
BACKGROUND/AIMS: Small-intestinal bacterial overgrowth (SIBO) is a frequent finding in patients with irritable bowel syndrome (IBS). Many patients with IBS also have abnormal intestinal permeability, which is probably due to...
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The changes of intestinal permeability in patients with mild acute pancreatitis

Kim JW, Jeon WK

  • KMID: 2256649
  • Korean J Med.
  • 2006 Jul;71(1):38-44.
BACKGROUND: Many studies in severe acute pancreatitis have demonstrated an increase in intestinal permeability, but not in mild acute pancreatitis. The current methods to measure intestinal permeability need much time...
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Effects of bovine colostrum in diclofenac induced gut injured rat model

Kim JW, Jeon WK, Chun HB, Kim YC, Yun JW, Park DI, Cho YK, Sung IK, Park CY, Sohn CI, Kim BI, Yeon JS, Park HS, Sohn JH, Kim EJ, Shin MS, Lee DH

  • KMID: 2252593
  • Korean J Med.
  • 2004 Jul;67(1):49-57.
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medicine but induce damage throughout the entire gastrointestinal tract including small intestine with protein and blood loss. Impaired epithelial barrier function, overgrowth...
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Relationship between excretion of 51Cr-EDTA and mucositis in patients with 5-FU based chemotherapy

Choi K, Choi HS, Kim YC, Kim JW, Oh SJ, Jeon WK, Kim EJ, Shin MS, Lee SS

  • KMID: 2306029
  • Korean J Med.
  • 2003 Dec;65(6):690-697.
BACKGROUND: Administration of anticancer drugs may damage gastrointestinal epithelium, thereby increasing the permeability of the gastrointestinal mucosa. It is known that intestinal permeability test using 51Cr-EDTA is a useful test...
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Antibodies to Saccharomyces cerevisiae in Patients with Inflammatory Bowel Disease and Its Correlation with Intestinal Permeability

Kim JS, Jung HC, Song IS, Kim CY, Kim YS, Lee JH

  • KMID: 2304608
  • Korean J Gastroenterol.
  • 2000 Aug;36(2):203-213.
BACKGROUND/AIMS: The antibody to oligomannosidic epitopes of the yeast Saccharomyces cerevisiae (ASCA) has been reported as a new serologic marker associated with Crohn's disease. We performed this study to assess...
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The Pathophysiology of Nonsteroidal Anti-inflammatory Drug Induced Enteropathy in Rat

Kim YS, Lee NR, Kim JS, Jung HC, Song IS, Kim CY

  • KMID: 2240287
  • Korean J Gastroenterol.
  • 2000 Jul;36(1):61-71.
BACKGROUND/AIMS: The pathophysiology of nonsteroidal anti-inflammatory drug (NSAID) induced enteropathy is still uncertain. It is proposed that an increase in intestinal permeability due to NSAID plays an important role in it. We...
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Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

Song IS, Kim CY, Jung HC, Kim TH, Chang DK, Kim JS, Lee CH

  • KMID: 1704036
  • Korean J Gastroenterol.
  • 1998 Oct;32(4):458-465.
BACKGROUND AND AIMS: Increased intestinal permeability has been proposed as an etiological factor of Crohn's disease (CD). This disease is rare in Korea, but has been increased recently. The aim...
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