- Optimal Pharmacologic Treatment of Chronic Constipation: Review and Recent Developments
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Shin JE
- KMID: 2307407
- Korean J Neurogastroenterol Motil.
- 2009 Dec;15(2):100-106.
Constipation is a common clinical problem that can be difficult to manage. Typical pharmacologic recommendations for patients with chronic constipation begin with bulking agents and then add osmotic agents followed... -
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- Lubiprostone Increases Small Intestinal Smooth Muscle Contractions Through a Prostaglandin E Receptor 1 (EP1)-mediated Pathway
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Chan WW, Mashimo H
- KMID: 2326230
- J Neurogastroenterol Motil.
- 2013 Jul;19(3):312-318.
BACKGROUND/AIMS: Lubiprostone, a chloride channel type 2 (ClC-2) activator, was thought to treat constipation by enhancing intestinal secretion. It has been associated with increased intestinal transit and delayed gastric emptying.... -
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- Helicobacter pylori Vacuolating Toxin Exhibits Polar Activity of Cl Secretion and Secretory Response to Carbachol in T84 Cells
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Jin NG, Jin YR, So I, Kim KW
- KMID: 1611434
- Korean J Physiol Pharmacol.
- 2004 Oct;8(5):289-293.
To investigate whether VacA (vacuolating toxin) produced by Helicobacter pylori Korean stain 99 induces intestinal secretion, purified VacA was added to T84 cell monolayers mounted in Ussing chambers, and electrical... -
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- cAMP-dependent signalling is involved in adenosine-stimulated Cl- secretion in rabbit colon mucosa
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Oh SO, Kim EY, Jung JS, Woo JS, Kim YK, Lee SH
- KMID: 2285215
- Korean J Physiol Pharmacol.
- 1998 Aug;2(4):521-527.
An important property of the intestine is the ability to secrete fluid. The intestinal secretion is regulated by a number of substances including vasoactive intestinal peptide (VIP), ATP and different inflammatory mediators. One... -
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