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Leucine-rich alpha-2 glycoprotein is useful in predicting clinical relapse in patients with Crohn’s disease during biological remission

Nakamura N, Honzawa Y, Ito Y, Sano Y, Yagi N, Kobayashi S, Aoi M, Tomiyama T, Tahara T, Fukata N, Fukui T, Naganuma M

Background/Aims: Serum leucine-rich alpha-2 glycoprotein (LRG) is a potential biomarker of Crohn’s disease (CD). This study aimed to evaluate the usefulness of LRG in predicting clinical relapse in patients in...
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Exploring the link between celiac disease and obesity: a potential role of gut microbiome

Addanki S, Mashukova A, Levy A

Background/Aims: In today’s age, celiac disease (CD) is no longer solely characterized by chronic diarrhea in a malnourished child. Obesity is gradually being acknowledged as part of CD’s clinical course....
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Response: Comments on “Adequacy of sigmoidoscopy as compared to colonoscopy for assessment of disease activity in patients of ulcerative colitis: a prospective study”

Patel ST, Chandnani S, Rathi PM

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Beyond mucosal healing: fecal calprotectin and the path toward histologic remission in ulcerative colitis

Park Y

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Does statin have a chemopreventive effect in patients with ulcerative colitis?

Jung YS

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Newly designed flared-end covered versus uncovered self-expandable metallic stents for palliation of malignant colorectal obstruction: a randomized, prospective study

Park SJ, Park Y, Lee HJ, Park JJ, Cheon JH, Kim WH, Kim TI

Background/Aims: Self-expandable metallic stents (SEMSs) are widely used as palliative or bridge to surgery treatments in patients with malignant colorectal obstruction (MCO). Stent occlusion is more common with uncovered stents,...
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Diagnostic performance of noninvasive tests for cytomegalovirus ileocolitis: a systematic review and meta-analysis

Chaemsupaphan T, Sattayalertyanyong O, Limsrivilai J

Background/Aims: Diagnosis of cytomegalovirus (CMV) ileocolitis traditionally requires colonoscopy with tissue biopsy. Due to potential complications in high-risk patients, there is growing interest in serum and stool tests for diagnosing...
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Role of 5-aminosalicylic acid in ulcerative colitis management in 8 Asian territories: a physician survey

Limsrivilai J, Lai AYh, Li STH, Abdullah M, Ali RAR, Aniwan S, Bui HH, Chou JW, Hilmi IN, Lim WC, Sollano J, Teo MMH, Wei SC, Leung WK

Clinical guidelines typically endorse conventional therapies such as 5-aminosalicylic acid (5-ASA) as the mainstay of ulcerative colitis management. However, the degree of adoption and application of guideline recommendations by physicians...
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Predictive accuracy of fecal calprotectin for histologic remission in ulcerative colitis

Singh A, Bhardwaj A, Sharma R, Kahlon BK, Dhaliwal AS, Singh D, Kaur S, Jain D, Bansal N, Mahajan R, Kaur K, Singh A, Narang V, Kaur H, Midha V, Sood A

Background/Aims: Accurate assessment of disease activity is crucial for effective management and treatment of ulcerative colitis (UC). This study evaluated the correlation between clinical, endoscopic, and histologic measures of disease...
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Histologic healing and clinical outcomes in ulcerative colitis

Liang RFH, Lin H, Chau CYP, Lim WC

Background/Aims: Growing evidence suggests histologic healing (HH) improves clinical outcomes in ulcerative colitis (UC) patients beyond endoscopic healing (EH). We hypothesize that HH is associated with better clinical outcomes in...
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Comments on “Adequacy of sigmoidoscopy as compared to colonoscopy for assessment of disease activity in patients of ulcerative colitis: a prospective study”

Harindranath S

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Early resolution of bowel urgency by budesonide foam enema results in improved quality of life in patients with ulcerative colitis: a multicenter prospective observational study

Kobayashi T, Moriya K, Fujii T, Bamba S, Shinzaki S, Yamada A, Hisabe T, Sagami S, Hibiya S, Amano T, Takatsu N, Inagaki K, Iwayama Ki, Hibi T

Background/Aims: Bowel urgency is an important symptom for quality of life determination in patients with ulcerative colitis (UC). Few clinical studies have focused on bowel urgency as an efficacy endpoint....
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Risk of malignancies and chemopreventive effect of statin, metformin, and aspirin in Korean patients with ulcerative colitis: a nationwide population-based study

Oh EH, Kim YJ, Kim M, Park SH, Kim TO, Park SH

Background/Aims: We investigated the incidences of overall and site-specific malignancies and chemopreventive effects of statin, metformin, and aspirin in patients with ulcerative colitis. Methods: We collected data using the Health Insurance...
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