- Epigenetic Dysfunction of Neurodegenerative Diseases, MeCP2 and More
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Im HI
- KMID: 2536156
- Int Neurourol J.
- 2022 Nov;26(Suppl 2):S83-84.
- doi: 10.5213/inj.2222edi04
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- Regulation of Αlpha-Synuclein Gene (SNCA) by Epigenetic Modifier TET1 in Parkinson Disease
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Guhathakurta S, Song MK, Basu S, Je G, Cristovao AC, Kim YS
- KMID: 2536157
- Int Neurourol J.
- 2022 Nov;26(Suppl 2):S85-93.
- doi: 10.5213/inj.2222206.103
Purpose: Deregulation of SNCA encoding α-synuclein (α-SYN) has been associated with both the familial and sporadic forms of Parkinson disease (PD). Epigenetic regulation plays a crucial role in PD. The... -
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- Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice
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Lee S, Kim TK, Choi JE, Kim HS, Im HI
- KMID: 2536159
- Int Neurourol J.
- 2022 Nov;26(Suppl 2):S106-116.
- doi: 10.5213/inj.2244254.127
Purpose: In Alzheimer disease (AD), brain regions such as the cortex and the hippocampus show abundant amyloid load which correlates with cognitive function decline. Prior to the significant development of... -
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- Changes in the Neuronal Architecture of the Hippocampus in a 6-Hydroxydopamine-Lesioned Rat Model of Parkinson Disease
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Kim B, Weerasinghe-Mudiyanselage PDE, Ang MJ, Lee J, Kang S, Kim JC, Kim SH, Kim JS, Jung C, Shin T, Moon C
- KMID: 2536158
- Int Neurourol J.
- 2022 Nov;26(Suppl 2):S94-105.
- doi: 10.5213/inj.2244252.126
Purpose: Parkinson disease (PD) is a progressive neurodegenerative disorder in which dopaminergic (DAergic) systems are destroyed (particularly in the nigrostriatal system), causing both motor and nonmotor symptoms. Hippocampal neuroplasticity is... -
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- Quantitative Sequencing Analysis of the Striatal Transcriptome in a Mouse Model of Alzheimer Disease
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Kim TK, Lee S, Im HI
- KMID: 2536160
- Int Neurourol J.
- 2022 Nov;26(Suppl 2):S117-125.
- doi: 10.5213/inj.2244256.128
Purpose: The purpose of this study was to analyze the transcriptomic changes in the striatum of amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice and uncover its association with the methyl-CpG... -
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- Brain Region-Dependent Alternative Splicing of Alzheimer Disease (AD)-Risk Genes Is Associated With Neuropathological Features in AD
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Kim S, Han S, Cho Sa, Nho K, Koh I, Lee Y
- KMID: 2536161
- Int Neurourol J.
- 2022 Nov;26(Suppl 2):S126-136.
- doi: 10.5213/inj.2244258.129
Purpose: Alzheimer disease (AD) is one of the most complex diseases and is characterized by AD-related neuropathological features, including accumulation of amyloid-β plaques and tau neurofibrillary tangles. Dysregulation of alternative... -
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