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Fusobacterium nucleatum infection induces CSF3 expression through p38 MAPK and JNK signaling pathways in oral squamous cell carcinoma cells

Jo A, Oh JM

Oral bacterial infections substantially affect the development of various periodontal diseases and oral cancers. However, the molecular mechanisms underlying the association between Fusobacterium nucleatum (F. nucleatum), a major periodontitis (PT)-associated pathogen,...
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Neuroprotective mechanism of corydaline in glutamate-induced neurotoxicity in HT22 cells

Selvaraj B, Kim DW, Yoo KY, Park K, Tran TTT, Lee JW, Lee H

Glutamate-mediated oxidative stress causes neuronal cell death by increasing intracellular Ca2+ uptake, reactive oxidative species (ROS) generation, mitogen-activated protein kinase (MAPK) activation, and translocation of apoptosis-inducing factor (AIF) to the...
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Efficacy of biological inhibitors in three-dimensional culture models of oral squamous cell carcinoma

Kim EK, Moon S, Lee MJ, Kim D

Despite advancements in therapeutic approaches, radiotherapy and cisplatin-based chemotherapy remain primary noninvasive treatments for patients with oral squamous cell carcinoma (OSCC). Moreover, the 5-year survival rate for patients with OSCC...
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