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Role of microglial activation on neuronal excitability in rat substantia gelatinosa

Park A, Chun SW

Glial cells, including astrocytes and microglia, interact closely with neurons and modulate pain transmission, particularly under pathological conditions. In this study, we examined the excitability of substantia gelatinosa (SG) neurons...
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Antitumor effects of octyl gallate on hypopharyngeal carcinoma cells

NTK T, Yoo H

The antitumor effects of octyl gallate (OG) were investigated on FaDu human hypopharyngeal squamous carcinoma cells. At various concentrations, OG inhibited the proliferation of FaDu cells by suppressing cell cycle...
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Induction of anti-aquaporin 5 autoantibodies by molecular mimicry in mice

Lee A, Choi Y

Molecular mimicry is the most common mechanism that breaches self-tolerance. We previously identified autoantibodies to aquaporin-5 (AQP5) in the sera of patients with Sjögren’s syndrome and found that the aquaporin...
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High-salt and glucose diet attenuates alveolar bone recovery in a ligature-induced rat model of experimental periodontitis

Lee W, Lee SH, Kim MS, Choi EJ

Excessive intake of sodium caused by high salt diet promotes the expression of inflammatory cytokines and differentiation of helper T cells resulting in inflammatory responses. High-glucose diet also contributes to...
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Increased SOX2 expression in three-dimensional sphere culture of dental pulp stem cells

Seo EJ, Jang IH

Mesenchymal stem cells in the dental pulp exhibit a tendency for differentiation into various dental lineages and hold great potential as a major conduit for regenerative treatment in dentistry. Although...
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Alteration of cellular events in tooth development by chemical chaperon, Tauroursodeoxycholic acid treatment

Lee ES, Aryal YP, Kim TY, Pokharel E, Kim H, Sung S, Sohn WJ, Lee Y, An CH, Kim JY

Several factors, including genetic and environmental insults, impede protein folding and secretion in the endoplasmic reticulum (ER). Accumulation of unfolded or mis-folded protein in the ER manifests as ER stress....
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Green tea polyphenol (–)-epigallocatechin-3-gallate prevents ultraviolet-induced apoptosis in PC12 cells

Woo SM, Kim YJ, Cai B, Park SY, Kim Y, Kim OJ, Kang IC, Kim WJ, Jung JY

Green tea polyphenol (–)-epigallocatechin-3-gallate (EGCG) is a potent antioxidant with protective effects against neurotoxicity. However, it is currently unclear whether EGCG protects neuronal cells against radiation-induced damage. Therefore, the objective...
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L-ascorbic acid induces apoptosis in human laryngeal epidermoid Hep-2 cells by modulating the nuclear factor kappa-light-chain-enhancer of activated B cells/ mitogen-activated protein kinase/Akt signaling pathway

Park JS, Kim YJ, Park SY, Chung KY, Oh SJ, Kim WJ, Jung JY

L-ascorbic acid (L-AA; vitamin C) induces apoptosis in cancer cells. This study aimed to elucidate the molecular mechanisms of L-AA-induced apoptosis in human laryngeal epidermoid carcinoma Hep-2 cells. L-AA suppressed...
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High concentration of calcium represses osteoblast differentiation in C2C12 cells

Lee YJ, Han Y

Calcium is the most abundant stored mineral in the human body and is especially vital for bone health; thus, calcium deficiency can cause bone-related diseases, such as osteopenia and osteoporosis....
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Anticancer effects of D-pinitol in human oral squamous carcinoma cells

Shin HC, Bang TH, Kang HM, Park BS, Kim IR

D-pinitol is an analog of 3-methoxy-D-chiro-inositol found in beans and plants. D-pinitol has anti-inflammatory, antidiabetic, and anticancer effects. Additionally, D-pinitol induces apoptosis and inhibits metastasis in breast and prostate cancers....
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Inhibitory effects of Coptis chinensis extract on the growth and biofilm formation of Streptococcus mutans and Streptococcus sobrinus

Kim SY, Song Y, Lee HA, Na HS, Jung CJ, Bek GY, Chung J

Streptococcus mutans and Streptococcus sobrinus play important roles in dental caries. Coptis chinensis is a natural product with antimicrobial activity against enterobacteria; however, its effects on oral streptococci are still...
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