- High concentration of calcium represses osteoblast differentiation in C2C12 cells
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Lee YJ, Han Y
- KMID: 2510196
- Int J Oral Biol.
- 2020 Dec;45(4):162-168.
- doi: 10.11620/IJOB.2020.45.4.162
Calcium is the most abundant stored mineral in the human body and is especially vital for bone health; thus, calcium deficiency can cause bone-related diseases, such as osteopenia and osteoporosis.... -
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- Anticancer effects of D-pinitol in human oral squamous carcinoma cells
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Shin HC, Bang TH, Kang HM, Park BS, Kim IR
- KMID: 2510194
- Int J Oral Biol.
- 2020 Dec;45(4):152-161.
- doi: 10.11620/IJOB.2020.45.4.152
D-pinitol is an analog of 3-methoxy-D-chiro-inositol found in beans and plants. D-pinitol has anti-inflammatory, antidiabetic, and anticancer effects. Additionally, D-pinitol induces apoptosis and inhibits metastasis in breast and prostate cancers.... -
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- Antitumor effects of octyl gallate on hypopharyngeal carcinoma cells
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NTK T, Yoo H
- KMID: 2510205
- Int J Oral Biol.
- 2020 Dec;45(4):218-224.
- doi: 10.11620/IJOB.2020.45.4.218
The antitumor effects of octyl gallate (OG) were investigated on FaDu human hypopharyngeal squamous carcinoma cells. At various concentrations, OG inhibited the proliferation of FaDu cells by suppressing cell cycle... -
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- Increased SOX2 expression in three-dimensional sphere culture of dental pulp stem cells
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Seo EJ, Jang IH
- KMID: 2510200
- Int J Oral Biol.
- 2020 Dec;45(4):197-203.
- doi: 10.11620/IJOB.2020.45.4.197
Mesenchymal stem cells in the dental pulp exhibit a tendency for differentiation into various dental lineages and hold great potential as a major conduit for regenerative treatment in dentistry. Although... -
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- Inhibitory effects of Coptis chinensis extract on the growth and biofilm formation of Streptococcus mutans and Streptococcus sobrinus
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Kim SY, Song Y, Lee HA, Na HS, Jung CJ, Bek GY, Chung J
- KMID: 2510191
- Int J Oral Biol.
- 2020 Dec;45(4):143-151.
- doi: 10.11620/IJOB.2020.45.4.143
Streptococcus mutans and Streptococcus sobrinus play important roles in dental caries. Coptis chinensis is a natural product with antimicrobial activity against enterobacteria; however, its effects on oral streptococci are still... -
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- Induction of anti-aquaporin 5 autoantibodies by molecular mimicry in mice
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Lee A, Choi Y
- KMID: 2510204
- Int J Oral Biol.
- 2020 Dec;45(4):211-217.
- doi: 10.11620/IJOB.2020.45.4.211
Molecular mimicry is the most common mechanism that breaches self-tolerance. We previously identified autoantibodies to aquaporin-5 (AQP5) in the sera of patients with Sjögren’s syndrome and found that the aquaporin... -
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- Role of microglial activation on neuronal excitability in rat substantia gelatinosa
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Park A, Chun SW
- KMID: 2510207
- Int J Oral Biol.
- 2020 Dec;45(4):225-231.
- doi: 10.11620/IJOB.2020.45.4.225
Glial cells, including astrocytes and microglia, interact closely with neurons and modulate pain transmission, particularly under pathological conditions. In this study, we examined the excitability of substantia gelatinosa (SG) neurons... -
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- High-salt and glucose diet attenuates alveolar bone recovery in a ligature-induced rat model of experimental periodontitis
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Lee W, Lee SH, Kim MS, Choi EJ
- KMID: 2510202
- Int J Oral Biol.
- 2020 Dec;45(4):204-210.
- doi: 10.11620/IJOB.2020.45.4.204
Excessive intake of sodium caused by high salt diet promotes the expression of inflammatory cytokines and differentiation of helper T cells resulting in inflammatory responses. High-glucose diet also contributes to... -
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- Green tea polyphenol (–)-epigallocatechin-3-gallate prevents ultraviolet-induced apoptosis in PC12 cells
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Woo SM, Kim YJ, Cai B, Park SY, Kim Y, Kim OJ, Kang IC, Kim WJ, Jung JY
- KMID: 2510198
- Int J Oral Biol.
- 2020 Dec;45(4):179-189.
- doi: 10.11620/IJOB.2020.45.4.179
Green tea polyphenol (–)-epigallocatechin-3-gallate (EGCG) is a potent antioxidant with protective effects against neurotoxicity. However, it is currently unclear whether EGCG protects neuronal cells against radiation-induced damage. Therefore, the objective... -
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- Alteration of cellular events in tooth development by chemical chaperon, Tauroursodeoxycholic acid treatment
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Lee ES, Aryal YP, Kim TY, Pokharel E, Kim H, Sung S, Sohn WJ, Lee Y, An CH, Kim JY
- KMID: 2510199
- Int J Oral Biol.
- 2020 Dec;45(4):190-196.
- doi: 10.11620/IJOB.2020.45.4.190
Several factors, including genetic and environmental insults, impede protein folding and secretion in the endoplasmic reticulum (ER). Accumulation of unfolded or mis-folded protein in the ER manifests as ER stress.... -
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- L-ascorbic acid induces apoptosis in human laryngeal epidermoid Hep-2 cells by modulating the nuclear factor kappa-light-chain-enhancer of activated B cells/ mitogen-activated protein kinase/Akt signaling pathway
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Park JS, Kim YJ, Park SY, Chung KY, Oh SJ, Kim WJ, Jung JY
- KMID: 2510197
- Int J Oral Biol.
- 2020 Dec;45(4):169-178.
- doi: 10.11620/IJOB.2020.45.4.169
L-ascorbic acid (L-AA; vitamin C) induces apoptosis in cancer cells. This study aimed to elucidate the molecular mechanisms of L-AA-induced apoptosis in human laryngeal epidermoid carcinoma Hep-2 cells. L-AA suppressed... -
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