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Ursodeoxycholic Acid Inhibits Inflammatory Cytokine Expression in THP-1 Cells Infected with Aggregatibacter actinomycetemcomitans

Song Y, Kim S, Park MH, Na HS, Chung J

BACKGROUND: Periodontitis is an inflammatory disease characterized by the breakdown of tooth-supporting tissues, leading to tooth loss. Aggregatibacter actinomycetemcomitans are major etiologic bacterium causing aggressive periodontitis. Ursodeoxycholic acid (UDCA), a...
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Anti-cariogenic Properties of α-Pinene, a Monoterpene in Plant Essential Oil

Park BI, You YO, Mo JS, An SY, Choi NY, Kim KJ

Dental caries is the most common chronic disease in the dental field. Streptococcus mutans (S. mutans) is the most important bacteria in the formation of dental plaque and dental caries....
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Chracterization of THP-1 Cell Death Induced by Porphyromonas gingivalis Infection

Song Y, Kim S, Park MH, Na HS, Chung J

BACKGROUND: Periodontitis is generally a chronic disorder characterized by the breakdown of tooth-supporting tissues. P. gingivalis, a Gram-negative anaerobic rod, is one of the major pathogens associated with periodontitis. Frequently,...
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Apoptosis Induction Effect of Zingiberis Rhizoma Extract in Microglia BV-2 Cells

Seo J, Oh MS, Jang YP, Kim JH

Microglia have multiple functions in regulating homeostasis of the central nervous system. Microglia cells have been implicated as active contributors to neuron damage in neurodegenerative disorders. In this study, medicinal...
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Peripheral Cellular Mechanisms of Artemin-induced Thermal Hyperalgesia in Rats

Kim HJ, Yang KY, Lee MK, Park MK, Son JY, Ju JS, Ahn DK

In the present study, we investigated the role of peripheral ionotropic receptors in artemin-induced thermal hyperalgesia in the orofacial area. Male Sprague-Dawley rats weighting 230 to 280 g were used...
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