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Retroviral-mediated IL-2 gene transfer into murine neuroblastoma

Cho HS, Song JY, Park CY, Lyu CJ, Kim BS, Kim KY

We used retroviral-mediated gene transfer of the human interleukin (IL)-2 gene into murine neuroblastoma cells to investigate whether locally-secreted IL-2 is able to influence the generation of anti-tumor immune responses....
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Effects of nitric oxide (NO) synthesis inhibition on antitumor responses during interleukin-2 (IL-2) treatment of mice

Yim CY, Lee CW, Choi SM, Park SS, Lee SJ, Kim JH, Song JS, Yoo WH, Kwak JY, Sohn MH

  • KMID: 1051549
  • Korean J Intern Med.
  • 1996 Jun;11(2):93-100.
OBJECTIVES: To evaluate if L-arginine: NO pathway is activated in tumor tissues during IL-2 therapy and to evaluate whether IL-2 induced NO synthesis represents an antitumor effector mechanism or an...
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