- Effects of Inosine Monophosphate Dehydrogenase Inhibition on Platelet-derived Growth Factor- Induced Fibronectin Secretion and Cellular Reactive Oxygen Species in Mouse Mesangial Cells
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Park J, Song JS, Huh KH, Ju MK, Chang HK, Ahn HJ, Kim MS, Kim YS
- KMID: 2201873
- J Korean Soc Transplant.
- 2007 Dec;21(2):210-215.
PURPOSE: Mesangial cell extracellular matrix (ECM) synthesis plays an important role in various renal diseases. Mycophenolic acid (MPA), which is an inhibitor of inosine monophosphate dehydrogenase (IMPDH), inhibits mesangial cell... -
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- Mycophenolic Acid Induced Apoptosis in Human Jurkat Cells viathe Generation of Reactive Oxygen Species
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Lee DK, Lee HK, Choi SJ, Chung SY
- KMID: 1476276
- J Korean Surg Soc.
- 2008 Sep;75(3):149-155.
PURPOSE: Mycophenolic acid (MPA) is the active agent of mycophenolate mofetil (MMF), which is an immunosuppressive drug. MPA is a selective inhibitor of inosine monophosphate dehydrogenase. The aim of this... -
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- Effects of Mycophenolate Mofetil on Acute Rejection of Allografted Kidney
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Kim HT, Cho WH, Park CH, Park SB, Kim HC
- KMID: 2144944
- J Korean Soc Transplant.
- 1998 Nov;12(2):253-260.
Mycophenolate mofetil (MMF) is a novel new immunosuppressant which suppress proliferation of T and B lymphocytes by inhibiting inosine monophosphate dehydrogenase. Even though the results we can get now are... -
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- Mizoribine Inhibits Production of Pro-inflammatory Cytokines and PGE2 in Macrophages
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Han S, Kim K, Kim H, Kwon J, Ha N, Lee CK, Kim K
- KMID: 2150625
- Immune Netw.
- 2007 Mar;7(1):31-38.
- doi: 10.4110/in.2007.7.1.31
BACKGROUND: Mizoribine (MZR) is an imidazole nucleoside isolated from Eupenicillium brefeldianum. MZR is currently in clinical use for patients who have undergone renal transplantation. Therapeutic efficacy of MZR has also... -
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- Mycophenolic Acid Induced Apoptotic Signal Transduction in Molt-4 T-cells
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Choi SJ, Chung SY, Kim SK
- KMID: 2004711
- J Korean Surg Soc.
- 2002 Jan;62(1):8-17.
PURPOSE: Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), is the active metabolite of the immunosuppressive drug, mycophenolate mofetil (MMF). MMF is used to prevent an immune-... -
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- Mizoribine-mediated Apoptosis Signaling in Jurkat T Cells
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Seo KW, Chung SH, Chung SY, Kim SK, Choi SN
- KMID: 1896293
- J Korean Surg Soc.
- 2004 Apr;66(4):259-270.
PURPOSE: Mizoribine (MZR), an inhibitor of Inosine monophosphate (IMP) dehydrogenase which depletes cellular GTP, is clinically used as an immunosuppressive drug. This study was designed to evaluate the mechanism by... -
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- Decision Factors on Mycophenolic Acid Dose after Renal Transplantation
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Kim SJ, Kim MS, Han DJ, Yang CW, Lee S, Yun IJ, Cho BS, Lee TW, Rim H, Kim MJ, Han DC, Shin GT, Oh CK, Do JY, Han SY, Choi SJ, Na KR
- KMID: 2097080
- J Korean Soc Transplant.
- 2009 Sep;23(2):135-140.
- doi: 10.4285/jkstn.2009.23.2.135
BACKGROUND: Triple immunosuppressant therapy including anti-metabolites is the representative immunosuppressive therapy after renal transplantation. This study is to evaluate the factors that influence Mycophenolate sodium (MPS, Myfortic, Novartis, Basel, Switzerland)... -
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