- Survivin Expression in Brain Tumors: Relevance of Apoptosis and Histological Malignancy
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Kim CH, Cheong JH, Bak KH, Kim JM, Ko Y, Oh SJ
- KMID: 2339688
- J Korean Neurosurg Soc.
- 2003 Jun;33(6):540-544.
OBJECTIVE: Survivin is one of the inhibitor of apoptosis protein family proteins, which inhibits apoptosis through pathway different from that involving the Bcl-2 family. Overexpression of survivin has been reported... -
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- Inhibitors of Apoptosis Proteins Expression and Their Prognostic Significance in Colorectal Carcinoma
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Lee KH, Lee S, Lee HM, Back SC, Cho SB, Lee JH
- KMID: 2277504
- Korean J Pathol.
- 2011 Aug;45(4):397-405.
BACKGROUND: The expression of the inhibitor of apoptosis proteins (IAPs) family has not been fully investigated in colorectal carcinomas. This study investigated IAP expression in colorectal carcinomas and assessed their... -
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- Identification of a Variant Form of Cellular Inhibitor of Apoptosis Protein (c-IAP2) That Contains a Disrupted Ring Domain
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Park SM, Kim JS, Park JH, Kang SG, Lee TH
- KMID: 1571515
- Immune Netw.
- 2002 Sep;2(3):137-141.
- doi: 10.4110/in.2002.2.3.137
Among the members of the inhibitor of apoptosis (IAP) protein family, only Livin and survivin have been reported to have variant forms. We have found a variant form of c-IAP2... -
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- The Immunohistochemical analysis for the expression of survivin, an inhibitor of apoptosis protein, in non-small cell lung cancer
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Ko MH, Myoung NH, Lee JW, Cho EM, Park JS, Kim KY, Lee KY
- KMID: 2160242
- Tuberc Respir Dis.
- 2000 Jun;48(6):909-921.
- doi: 10.4046/trd.2000.48.6.909
BACKGROUND: Defects in apoptotic signaling pathways play important role in tumor initiation, progression, metastasis and resistance to treatment. Several proteins which may promote tumorigenesis by inhibiting apoptosis were identified. The... -
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- Expression of c-IAP1, c-IAP2 as of Inhibitor of Apoptosis Proteins in Cervical and Ovarian Cancers
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Cho JH, Cho CH, Kwon SH, Baek WK, Kwon KY, Park JC, Rhee JH, Kim JI, Yoon SD, Cha SD
- KMID: 1615587
- Korean J Gynecol Oncol Colposc.
- 2003 Mar;14(1):21-29.
OBJECTIVE: The inhibitor of apoptosis proteins (IAPs) constitutes a family of highly conserved apoptosis suppressor proteins that were originally identified in baculoviruses. Although IAP homologs have recently been demonstrated to... -
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- Relationship between Expression of XIAP Protein in Operable Non- small Cell Lung Carcinomas and Apoptosis Index and Postoperative Prognosis
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Kim SH, Lee CH, Sol MY, Song JM, Lee JH, Lee MK, Kim JM
- KMID: 2318616
- Tuberc Respir Dis.
- 2005 May;58(5):480-489.
BACKGROUND: Dysregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. X-linked inhibitor of apoptosis (XIAP) is considered to be the most potent caspase inhibitor... -
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- Expression of Survivin and HSP90 in Colorectal Cancer and its Relationship with Clinicopathologic Factors
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Kim TH, Lee TJ, Kim BG, Cha SJ, Park SJ, Lim HM, Park SI
- KMID: 1940507
- J Korean Surg Soc.
- 2006 Feb;70(2):113-119.
PURPOSE: Survivin is an inhibitor of apoptosis protein and it is overexpressed in most human cancers. Recent data demonstrated that survivin-HSP90 complex regulate apoptosis. We assessed expression of survivin and... -
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- Anti-apoptosis Gene, Survivin Expression and Prognosis of Neuroblstoma
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Ahn SM, Oh JT, Han SJ, Hwang EH, Choi SH
- KMID: 2096241
- J Korean Surg Soc.
- 2005 Jan;68(1):56-60.
PURPOSE: The prognostic significance of survivin expression (SE), which has been reported to be an inhibitor of apoptosis protein, was examined in order to identify a more accurate prognostic grouping... -
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- Prognostic Value of Phosphorylated Akt and Survivin Expression in Gastric Adenocarcinoma
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Lee S, Kim YC, Lee HM, Lee KS, Shin BC, Kim HS, Lee JH, Park CS, Lee KH
- KMID: 1837528
- Korean J Pathol.
- 2010 Jun;44(3):252-258.
BACKGROUND: pAkt (the phosphorylated form of the proto-oncogene protein c-akt) and survivin (human BIRC5 protein) are candidate apoptosis-related molecules that may be responsible for cancer progression. The aim of this study... -
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- Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells
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Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR
- KMID: 1110128
- Exp Mol Med.
- 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis... -
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- Evaluation of the Expression of the Inhibitor of Apoptosis Protein Family and Human Telomerase Reverse Transcriptase in Patients With Advanced Colorectal Adenoma
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Choi JY, Yoon H, Na G, Choi YJ, Shin CM, Park YS, Kim N, Lee DH
- KMID: 2400773
- J Cancer Prev.
- 2017 Jun;22(2):98-102.
- doi: 10.15430/JCP.2017.22.2.98
BACKGROUND: It has been reported that the expression of the inhibitor of apoptosis protein (IAP) family increases in patients with colon cancer. We evaluated the expression of the IAP family... -
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- The Expression of Vascular Endothelial Growth Factor(VEGF) and Survivin in Squamous Cell Carcinoma of Larynx
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Kim HJ, Kim KH, Jang YD, Cho SH, Koh YW, Kim DW, Lee BD, Chang HS
- KMID: 1593101
- Korean J Otolaryngol-Head Neck Surg.
- 2006 Dec;49(12):1188-1193.
BACKGROUND AND OBJECTIVES: Angiogenesis and alteration of apoptosis are hypothesized to be the mechanisms of the growth of tumor. Vascular endothelial growth factor (VEGF) is considered to be the most... -
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- Overexpression of c-IAP1 , a Member of the Inhibitor of Apoptosis , Identified by cDNA Microarray Technique in Ovarian Carcinomas
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Cho CH, Lee TS, Cha SD, Baek WK, Seo SI, Seo MH, Park KG, Jung NC, Bae IS, Kwak JS
- KMID: 2075834
- Korean J Obstet Gynecol.
- 1999 Jul;42(7):1556-1563.
OBJECTIVE: Programmed cell death or apoptosis is a fundamental event in the developmental and homeostatic processes of all multicellular organisms. In this study, we preliminarily evaluated comparative patterns of gene... -
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- Antichemosensitizing effect of resveratrol in cotreatment with oxaliplatin in HCT116 colon cancer cell
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Park DG
- KMID: 1908500
- Ann Surg Treat Res.
- 2014 Feb;86(2):68-75.
- doi: 10.4174/astr.2014.86.2.68
PURPOSE: Although oxaliplatin is one of the most widely used chemotherapeutic agents for the treatment of advanced stages of colorectal cancers in clinic, cancer cells often develop oxaliplatin drug resistance.... -
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- Detection of Survivin and COX-2 in Thyroid Carcinoma: Anaplastic Carcinoma Shows Overexpression of Nuclear Survivin and Low COX-2 Expression
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Kim YA, Chang M, Park YJ, Kim JE
- KMID: 1439778
- Korean J Pathol.
- 2012 Feb;46(1):55-60.
- doi: 10.4132/KoreanJPathol.2012.46.1.55
BACKGROUND: Overexpression of survivin, a member of the inhibitors of apoptosis protein, has been reported in various carcinomas, and its interaction with cyclooxygenase 2 (COX-2) results in accelerated tumor progression.... -
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- Protective Effect of Survivin in Doxorubicin-Induced Cell Death in H9c2 Cardiac Myocytes
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Lee BS, Kim SH, Jin T, Choi EY, Oh J, Park S, Lee SH, Chung JH, Kang SM
- KMID: 2224901
- Korean Circ J.
- 2013 Jun;43(6):400-407.
- doi: 10.4070/kcj.2013.43.6.400
BACKGROUND AND OBJECTIVES: Apoptosis has been known to be an important mechanism of doxorubicin-induced cardiotoxicity. Survivin, which belongs to the inhibitor of apoptosis protein family, is associated with apoptosis and... -
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- Effects of Transplantation with Marrow-Derived Mesenchymal Stem Cells Modified with Survivin on Renal Ischemia-Reperfusion Injury in Mice
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Yuzeng Q, Weiyang H, Xin G, Qingson Z, Youlin K, Ke R
- KMID: 2130843
- Yonsei Med J.
- 2014 Jul;55(4):1130-1137.
- doi: 10.3349/ymj.2014.55.4.1130
PURPOSE: To determine whether renal injury induced by ischemia-reperfusion (I/R) could be further improved by mesenchymal stem cells (MSCs) modified with survivin. MATERIALS AND METHODS: Lentiviral vectors were used to introduce... -
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- Helicobacter pylori Eradication Downregulates Cellular Inhibitor of Apoptosis Protein 2 in Gastric Carcinogenesis
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Yoon H, Kim SG, Kim BK, Shin E, Kim N, Lee HJ, Kang GH, Jung HC
- KMID: 2412158
- Gut Liver.
- 2017 Jan;11(1):79-86.
- doi: 10.5009/gnl15585
BACKGROUND/AIMS: To evaluate the expression of cellular inhibitor of apoptosis protein 2 (cIAP2) during gastric carcinogenesis after Helicobacter pylori (HP) infection and after HP eradication. METHODS: We divided non-cancer patients into... -
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- Paxilline enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5
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Kang YJ, Kim IY, Kim EH, Yoon MJ, Kim SU, Kwon TK, Choi KS
- KMID: 991620
- Exp Mol Med.
- 2011 Jan;43(1):24-34.
- doi: 10.3858/emm.2011.43.1.003
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) induces apoptosis selectively in cancer cells while sparing normal cells. However, many cancer cells are resistant to TRAIL-induced cell death. Here, we report that... -
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- Expression of survivin in squamous cell carcinoma and transitional cell carcinoma of the urinary bladder: A comparative immunohistochemical study
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Makboul R, Refaiy AE, Badary FA, Abdelkawi , Merseburger AS, Mohammed R
- KMID: 2070266
- Korean J Urol.
- 2015 Jan;56(1):31-40.
- doi: 10.4111/kju.2015.56.1.31
PURPOSE: To compare the expression of survivin and its association with clinicopathological criteria in major types of urinary bladder carcinoma, specifically, transitional cell carcinoma with and without squamous differentiation and... -
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