- New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development
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Kurashima , Kiyono H
- KMID: 2155348
- Exp Mol Med.
- 2014 Mar;46(3):e83.
- doi: 10.1038/emm.2014.7
To achieve immune homeostasis in such a harsh environment as the intestinal mucosa, both active and quiescent immunity operate simultaneously. Disruption of gut immune homeostasis leads to the development of... -
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- Sensitization to and Challenge with Gliadin Induce Pancreatitis and Extrapancreatic Inflammation in HLA-DQ8 Mice: An Animal Model of Type 1 Autoimmune Pancreatitis
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Moon SH, Kim J, Kim MY, Park DH, Song TJ, Kim SA, Lee SS, Seo DW, Lee SK, Kim MH
- KMID: 2412084
- Gut Liver.
- 2016 Sep;10(5):842-850.
- doi: 10.5009/gnl15484
BACKGROUND/AIMS: The aim of this study was to establish a pathogenetic mechanism of pancreatitis in celiac disease and IgG4-related disease using gluten-sensitive human leukocyte antigen (HLA)-DQ8 transgenic mice. METHODS: Transgenic mice... -
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- Celastrol inhibits production of nitric oxideandproinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells
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Jung HW, Chung YS, Kim YS, Park YK
- KMID: 1091066
- Exp Mol Med.
- 2007 Dec;39(6):715-721.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as... -
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- Recent Advances in Mechanisms and Treatments of Airway Remodeling in Asthma: A Message from the Bench Side to the Clinic
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Cho JY
- KMID: 1729239
- Korean J Intern Med.
- 2011 Dec;26(4):367-383.
- doi: 10.3904/kjim.2011.26.4.367
Airway remodeling in asthma is a result of persistent inflammation and epithelial damage in response to repetitive injury. Recent studies have identified several important mediators associated with airway remodeling in... -
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- Upregulation of Proinflammatory Cytokines in the Fetal Brain of the Gaucher Mouse
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Hong YB, Kim EY, Jung SC
- KMID: 2157830
- J Korean Med Sci.
- 2006 Aug;21(4):733-738.
- doi: 10.3346/jkms.2006.21.4.733
Gaucher disease is caused by a deficiency of glucocerebrosidase. Patients with Gaucher disease are divided into three major phenotypes: chronic nonneuronopathic, acute neuronopathic, and chronic neuronopathic, based on symptoms of... -
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- Inflammation affects the viability and plasticity of equine mesenchymal stem cells: possible implications in intra-articular treatments
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Barrachina L, Remacha AR, Romero A, Vázquez F, Albareda J, Prades M, Ranera B, Zaragoza P, MartÃn-Burriel I, Rodellar C
- KMID: 2412586
- J Vet Sci.
- 2017 Mar;18(1):39-49.
- doi: 10.4142/jvs.2017.18.1.39
Mesenchymal stem cells (MSCs) are gaining relevance for treating equine joint injuries because of their ability to limit inflammation and stimulate regeneration. Because inflammation activates MSC immunoregulatory function, proinflammatory priming... -
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- Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-gamma
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Lee BJ, Moon HG, Shin TS, Jeon SG, Lee EY, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK
- KMID: 1104386
- Exp Mol Med.
- 2011 Apr;43(4):169-178.
- doi: 10.3858/emm.2011.43.4.018
Recent clinical evidence indicates that the non-eosinophilic subtype of severe asthma is characterized by fixed airway obstruction, which may be related to emphysema. Transgenic studies have demonstrated that high levels... -
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- Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism at TLR4
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Lee SH, Kang MJ, Yu HS, Hong K, Jung YH, Kim HY, Seo JH, Kwon JW, Kim BJ, Kim HJ, Kim YJ, Kim HS, Kim HB, Park KS, Lee SY, Hong SJ
- KMID: 1786107
- J Korean Med Sci.
- 2014 May;29(5):662-668.
- doi: 10.3346/jkms.2014.29.5.662
The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress. Toll-like receptor 4 (TLR4) plays a critical role not... -
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- Serum Leptin and Adiponectin Levels in Korean Patients with Psoriasis
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Oh YJ, Lim HK, Choi JH, Lee JW, Kim NI
- KMID: 1786117
- J Korean Med Sci.
- 2014 May;29(5):729-734.
- doi: 10.3346/jkms.2014.29.5.729
Psoriasis is a disorder caused by genetic and immunological factors. Leptin, a peptide hormone secreted predominantly from adipose tissue, regulates energy intake and expenditure, as well as the T-helper response.... -
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