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Understanding the Host Innate Immune Responses against SARS-CoV-2 Infection and COVID-19 Pathogenesis

Kang YW, Park S, Lee KJ, Moon D, Kim YM, Lee SW

The emergence of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a significant health concern worldwide. Undoubtedly, a better understanding of the innate and adaptive immune...
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Adenovirus Vectors: Excellent Tools for Vaccine Development

Chang J

Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its...
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COVID-19 Antiviral and Treatment Candidates: Current Status

Españo E, Kim D, Kim J, Park SK, Kim JK

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 has severely impacted global health and economy. There is currently no effective approved treatment for...
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SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals

Rha MS, Kim AR, Shin EC

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In the current review, we describe SARS-CoV-2-specific CD4 + and CD8 + T-cell...
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Current Status of COVID-19 Vaccine Development: Focusing on Antigen Design and Clinical Trials on Later Stages

Lee P, Kim CU, Seo SH, Kim DJ

The global outbreak of coronavirus disease 2019 (COVID-19) is still threatening human health, economy, and social life worldwide. As a counteraction for this devastating disease, a number of vaccines are...
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Single Cell Transcriptomic Re-analysis of Immune Cells in Bronchoalveolar Lavage Fluids Reveals the Correlation of B Cell Characteristics and Disease Severity of Patients with SARS-CoV-2 Infection

Kim CW, Oh JE, Lee HK

The coronavirus disease 2019 (COVID-19) pandemic (severe acute respiratory syndrome coronavirus 2) is a global infectious disease with rapid spread. Some patients have severe symptoms and clinical signs caused by...
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SARS-CoV-2 Infection of Airway Epithelial Cells

Ryu G, Shin HW

Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) has been spreading worldwide since its outbreak in December 2019, and World Health Organization declared it as a...
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Ongoing Clinical Trials of Vaccines to Fight against COVID-19 Pandemic

Chakraborty C, Sharma AR, Bhattacharya M, Sharma G, Saha RP, Lee SS

Coronavirus disease 2019 (COVID-19) has developed as a pandemic, and it created an outrageous effect on the current healthcare and economic system throughout the globe. To date, there is no...
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Transmission Characteristics of SARSCoV-2 That Hinder Effective Control

Bae S, Lim JS, Kim JY, Jung J, Kim SH

The most important characteristics of coronavirus disease 2019 (COVID-19) transmission that makes it difficult to control are 1) asymptomatic and presymptomatic transmission, 2) low incidence or lack of dominant systemic...
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Sputum Processing Method for Lateral Flow Immunochromatographic Assays to Detect Coronaviruses

Kang A, Yeom M, Kim H, Yoon SW, Jeong DG, Moon HJ, Lyoo KS, Na W, Song D

Coronavirus causes an infectious disease in various species and crosses the species barriers leading to the outbreak of zoonotic diseases. Due to the respiratory diseases are mainly caused in humans...
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Structure of SARS-CoV-2 Spike Glycoprotein for Therapeutic and Preventive Target

Hong J, Jhun H, Choi YO, Taitt AS, Bae S, Lee Y, Song Cs, Yeom SC, Kim S

The global crisis caused by the coronavirus disease 2019 (COVID-19) led to the most significant economic loss and human deaths after World War II. The pathogen causing this disease is...
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