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A “Prime and Deploy” Strategy for Universal Influenza Vaccine Targeting Nucleoprotein Induces Lung-Resident Memory CD8 T cells

Chung H, Kim EA, Chang J

Lung-resident memory T cells (TRM ) play an essential role in protecting against pulmonary virus infection. Parenteral administration of DNA vaccine is generally not sufficient to induce lung CD8 T...
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Monocytes Contribute to IFN-β Production via the MyD88-Dependent Pathway and Cytotoxic T-Cell Responses against Mucosal Respiratory Syncytial Virus Infection

Kim TH, Kim CW, Oh DS, Jung HE, Lee HK

Respiratory syncytial virus (RSV) is the leading cause of respiratory viral infection in infants and children. However, little is known about the contribution of monocytes to antiviral responses against RSV...
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Comparison of Antibody and T Cell Responses Induced by Single Doses of ChAdOx1 nCoV-19 and BNT162b2 Vaccines

Kim JY, Bae S, Park S, Kwon JS, Lim SY, Park JY, Cha HH, Seo MH, Lee HJ, Lee N, Heo J, Shum D, Jee Y, Kim SH

There are limited data directly comparing humoral and T cell responses to the ChAdOx1 nCoV-19 and BNT162b2 vaccines. We compared Ab and T cell responses after first doses of ChAdOx1...
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Tumor-Infiltrating Neutrophils and Non-Classical Monocytes May Be Potential Therapeutic Targets for HER2 negative Gastric Cancer

Jeong J, Kim DK, Park JH, Park DJ, Lee HJ, Yang HK, Kong SH, Jung K

Gastric cancer (GC) is the fourth most common cause of cancer-related death globally. The classification of advanced GC (AGC) according to molecular features has recently led to effective personalized cancer...
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Mitofusin-2 Promotes the EpithelialMesenchymal Transition-Induced Cervical Cancer Progression

Ahn SY, Song J, Kim YC, Kim MH, Hyun YM

High expression of mitofusin-2 (MFN2), a mitochondrial fusion protein, has been frequently associated with poor prognosis of patients with cervical cancer. Here, we aimed to identify the function of MFN2...
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Interactions between NCR + ILC3s and the Microbiome in the Airways Shape Asthma Severity

Ham J, Kim J, Choi S, Park J, Baek Mg, Kim YC, Sohn KH, Cho SH, Yang S, Bae YS, Chung DH, Won S, Yi H, Kang HR, Kim HY

Asthma is a heterogeneous disease whose development is shaped by a variety of environmental and genetic factors. While several recent studies suggest that microbial dysbiosis in the gut may promote...
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Indoleamine 2,3-Dioxygenase in Hematopoietic Stem Cell-Derived Cells Suppresses Rhinovirus-Induced Neutrophilic Airway Inflammation by Regulating Th1- and Th17-Type Responses

Hossain FMA, Park SO, Kim HJ, Eo JC, Choi JY, Tanveer M, Uyangaa E, Kim K, Eo SK

Asthma exacerbations are a major cause of intractable morbidity, increases in health care costs, and a greater progressive loss of lung function. Asthma exacerbations are most commonly triggered by respiratory...
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