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Microbiota Influences Vaccine and Mucosal Adjuvant Efficacy

Kim YG

A symbiotic relationship between humans and the microbiota is critical for the maintenance of our health, including development of the immune system, enhancement of the epithelial barrier, and acquisition of...
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The Specific Roles of Vitamins in the Regulation of Immunosurveillance and Maintenance of Immunologic Homeostasis in the Gut

Hosomi K, Kunisawa J

Vitamins are micronutrients which are essential for the maintenance of biological responses including immune system. Hence, vitamin deficiency increases a risk of infectious, allergic, and inflammatory diseases. Accumulating evidence has...
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Emerging Roles of Lymphatic Vasculature in Immunity

Kim KW, Song JH

The lymphatic vasculature has been regarded as a passive conduit for interstitial fluid and responsible for the absorption of macromolecules such as proteins or lipids and transport of nutrients from...
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Regulatory Eosinophils in Inflammation and Metabolic Disorders

Yang BG, Seoh JY, Jang MH

Eosinophils are potent effector cells implicated in allergic responses and helminth infections. Responding to stimuli, they release their granule-derived cytotoxic proteins and are involved in inflammatory processes. However, under homeostatic...
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Beyond Hygiene: Commensal Microbiota and Allergic Diseases

Hong SW, Kim KS, Surh CD

Complex communities of microorganisms, termed commensal microbiota, inhabit mucosal surfaces and profoundly influence host physiology as well as occurrence of allergic diseases. Perturbing factors such as the mode of delivery,...
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Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies

Kim DH, Cheon JH

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder with an unknown etiology. IBD is composed of two different disease entities: Crohn's disease (CD) and ulcerative colitis (UC). IBD...
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Immune Cell Responses and Mucosal Barrier Disruptions in Chronic Rhinosinusitis

Khalmuratova R, Park JW, Shin HW

Chronic rhinosinusitis (CRS) is one of the most common presentations of upper airway illness and severely affects patient quality of life. Its frequency is not surprising given levels of environmental...
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Host-microbial Cross-talk in Inflammatory Bowel Disease

Nagao-Kitamoto H, Kamada N

A vast community of commensal microorganisms, commonly referred to as the gut microbiota, colonizes the gastrointestinal tract (GI). The involvement of the gut microbiota in the maintenance of the gut...
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