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Peroxiredoxin-3 Is Involved in Bactericidal Activity through the Regulation of Mitochondrial Reactive Oxygen Species

Lee S, Wi SM, Min Y, Lee KY

Peroxiredoxin-3 (Prdx3) is a mitochondrial protein of the thioredoxin family of antioxidant peroxidases and is the principal peroxidase responsible for metabolizing mitochondrial hydrogen peroxide. Recent reports have shown that mitochondrial...
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Interleukin 17-expressing Innate Synovial Cells Drive K/Bxn Serum-induced Arthritis

Cho WS, Jang E, Kim HY, Youn J

K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of...
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Induction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis

Ryu DB, Lim JY, Lee SE, Park G, Min CK

Mesenchymal stem cells (MSCs) have been used experimentally for treating inflammatory disorders, partly owing to their immunosuppressive properties. The goal of the study was to determine whether TLR ligands can...
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Reference Values for a Panel of Cytokinergic and Regulatory Lymphocyte Subpopulations

Sorrenti V, Marenda B, Fortinguerra S, Cecchetto , Quartesan , Zorzi G, Zusso M, Giusti P, Buriani A

Lymphocyte subpopulations producing cytokines and exerting regulatory functions represent key immune elements. Given their reciprocal interdependency lymphocyte subpopulations are usually assayed as diagnostic panels, rather than single biomarkers for specialist...
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Folate Receptor-Targeted Diagnostics and Therapeutics for Inflammatory Diseases

Yi YS

Inflammation, an innate immune response mediated by macrophages, forms the first line of defence to protect our body from the invasion of various pathogens. Although inflammation is a defensive response,...
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Regulatory T Cells in Hepatitis B and C Virus Infections

Jung MK, Shin EC

Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury....
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Unusual CD4⁺CD28⁻ T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders

Lee GH, Lee WW

CD28 is a primary co-stimulatory receptor that is essential for successful T cell activation, proliferation, and survival. While ubiquitously expressed on naive T cells, the level of CD28 expression on...
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Neutrophil Extravasation Cascade: What Can We Learn from Two-photon Intravital Imaging?

Park SA, Hyun YM

Immune cells (leukocytes or white blood cells) move actively and sensitively based on body conditions. Despite their important role as protectors inside the body, it is difficult to directly observe...
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