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Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells

Oh YK, Jang E, Paik DJ, Youn J

Early growth response (Egr)-1 is a Cys2-His2-type zincfinger transcription factor. It has been shown to induce survival and proliferation of immature and mature B cells, respectively, but its role in...
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Effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on Immune Functions in Healthy Adults in a Randomized Controlled Trial

Hwang HJ, Sohn KY, Han YH, Chong S, Yoon SY, Kim YJ, Jeong J, Kim SH, Kim JW

We previously reported that 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) accelerates hematopoiesis and has an improving effect on animal disease models such as sepsis and asthma. The effects of PLAG supplementation on immune modulation...
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Osteopontin Potentiates Pulmonary Inflammation and Fibrosis by Modulating IL-17/IFN-gamma-secreting T-cell Ratios in Bleomycin-treated Mice

Oh K, Seo MW, Kim YW, Lee DS

Lung fibrosis is a life-threatening disease caused by overt or insidious inflammatory responses. However, the mechanism of tissue injury-induced inflammation and subsequent fibrogenesis remains unclear. Recently, we and other groups...
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Alloferon Alleviates Dextran Sulfate Sodium-induced Colitis

Kim H, Im JP, Kim JS, Kang JS, Lee WJ

Dysfunction of gut immune regulation is involved in mucosal damage in inflammatory bowel disease (IBD). However, there is still no efficacious immune-regulator for the treatment of IBD. Alloferon is a...
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Attenuation of Hepatic Graft-versus-host Disease in Allogeneic Recipients of MyD88-deficient Donor Bone Marrow

Lim JY, Lee YK, Lee SE, Ju JM, Park G, Choi EY, Min CK

Acute graft-versus-host-disease (GVHD) is characterized by selective damage to the liver, the skin, and the gastrointestinal tract. Following allogeneic hematopoietic stem cell transplantation, donor bone marrow (BM) cells repopulate the...
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Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?

Kwon B

Now, it has been being accepted that reverse signaling through CD137 ligand (CD137L) plays an important role in vivo during hematopoiesis and in immune regulation. However, due to technical difficulty...
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The Role of Dendritic Cells in Central Tolerance

Oh J, Shin JS

Dendritic cells (DCs) play a significant role in establishing self-tolerance through their ability to present self-antigens to developing T cells in the thymus. DCs are predominantly localized in the medullary...
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