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Immunostimulatory Effects of Silica Nanoparticles in Human Monocytes

Yang EJ, Choi IH

Amorphous silica particles, whose applications are increasing in many biomedical fields, are known to be less toxic than crystalline silica. In this study, the inflammatory effects of amorphous silica nanoparticles...
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Sublingual Delivery of Vaccines for the Induction of Mucosal Immunity

Shim BS, Choi Y, Cheon IS, Song MK

The mucosal surfaces are constantly exposed to incoming pathogens which can cause infections that result in severe morbidity and/or mortality. Studies have reported that mucosal immunity is important for providing...
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Priming of Autoreactive CD8+ T Cells Is Inhibited by Immunogenic Peptides Which Are Competitive for Major Histocompatibility Complex Class I Binding

You S, Choi YS, Hong S, Shin EC

In the present study, we investigated if priming of autoreactive CD8+ T cells would be inhibited by competitive peptides for major histocompatibility complex (MHC) class I binding. We used a...
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Extravasating Neutrophil-derived Microparticles Preserve Vascular Barrier Function in Inflamed Tissue

Lim K, Sumagin R, Hyun YM

Emerging evidence suggests that gap formation and opening of the endothelial junctions during leukocyte extravasation is actively controlled to maintain the integrity of the vascular barrier. While the role for...
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Skin Graft-versus-host Disease Following Autologous Stem Cell Transplantation for Multiple Myeloma

Lee SE, Yoon JH, Shin SH, Park G, Min CK

Graft-versus-host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). However, a similar syndrome has been reported in autologous stem cell transplantation (ASCT) as well. The target...
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