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Influence of the Adjuvants and Genetic Background on the Asthma Model Using Recombinant Der f 2 in Mice

Chang YS, Kim YK, Jeon SG, Kim SH, Kim SS, Park HW, Min KU, Kim YY, Cho SH

Der f 2 is the group 2 major allergen of a house dust mite (Dermatophagoides farinae) and its function has been recently suggested. To determine the optimal condition of sensitization...
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Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain

Jha MK, Jeon S, Jin M, Lee WH, Suk K

Lipocalin-2 (LCN2) is an acute-phase protein induced by injury, infection, or other inflammatory stimuli. LCN2 binds small hydrophobic ligands and interacts with cell surface receptor to regulate diverse cellular processes....
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BIRB 796 has Distinctive Anti-inflammatory Effects on Different Cell Types

Ryoo S, Choi J, Kim J, Bae S, Hong J, Jo S, Kim S, Lee Y

The pro-inflammatory cytokines tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-1beta are crucial mediators involved in chronic inflammatory diseases. Inflammatory signal pathways regulate inflammatory cytokine expression-mediated by p38 mitogen activated protein...
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Mucosal Immunization with Recombinant Adenovirus Encoding Soluble Globular Head of Hemagglutinin Protects Mice Against Lethal Influenza Virus Infection

Kim JY, Choi Y, Nguyen HH, Song MK, Chang J

Influenza virus is one of the major sources of respiratory tract infection. Due to antigenic drift in surface glycoproteins the virus causes annual epidemics with severe morbidity and mortality. Although...
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Detection of Foreign Antigen-specific CD4+Foxp3+ Regulatory T Cells by MHC Class II Tetramer and Intracellular CD154 Staining

Choi JY, Eo SK

The unrestricted population of CD4+Foxp3+ regulatory T (Treg) cells, which have been known to control the expression of autoimmune diseases and protective immunity to inflammatory reactions, has led to greater...
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CP-690550 Treatment Ameliorates Established Disease and Provides Long-Term Therapeutic Effects in an SKG Arthritis Model

Oh K, Seo MW, Kim IG, Hwang YI, Lee HY, Lee DS

Although pathogenesis of human rheumatoid arthritis (RA) remains unclear, arthritogenic T cells and downstream signaling mediators have been shown to play critical roles. An increasing numbers of therapeutic options have...
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IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses

Kim S, Karasuyama H, Lopez AF, Ouyang W, Li X, Le Gros G, Min B

How Th2 immunity develops in vivo remains obscure. Basophils have been considered key innate cells producing IL-4, a cytokine essential for Th2 immunity. Increasing evidence suggests that basophils are dispensable...
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Increased Lymphocyte Infiltration in Rheumatoid Arthritis Is Correlated with an Increase in LTi-like Cells in Synovial Fluid

Koo J, Kim S, Jung WJ, Lee YE, Song GG, Kim KS, Kim MY

In this study, we compared the immune cell populations in rheumatoid arthritis (RA) synovial fluid, which shows lymphoid tissue-like structure, with those in tonsils, which are normal secondary lymphoid tissues....
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Encapsulated Islet Transplantation: Strategies and Clinical Trials

Buder B, Alexander , Krishnan R, Chapman DW, Lakey JR

Encapsulation of tissue has been an area of intense research with a myriad number of therapeutic applications as diverse as cancer, tissue regeneration, and diabetes. In the case of diabetes,...
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Regulation of Intestinal Homeostasis by Innate Immune Cells

Kayama H, Nishimura , Takeda K

The intestinal immune system has an ability to distinguish between the microbiota and pathogenic bacteria, and then activate pro-inflammatory pathways against pathogens for host defense while remaining unresponsive to the...
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