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Meaning of the DR-70(TM) Immunoassay for Patients with the Malignant Tumor

Lee KH, Cho DH, Kim KM, Kim SM, Lee DJ

BACKGROUND: The DR-70(TM) immunoassay is a newly developed cancer diagnostic test which quantifies the serum fibrin degradation products (FDP), produced during fibrinolysis, by antibody reaction. The purpose of this study...
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Expression and Function of Calcineurin in Inflammatory Arthritis

Park BH, Yoo SA, Hong KH, Hyoung BJ, Hwang YN, Cho CS, Park W, Kim WU

BACKGROUND: Calcineurin plays a crucial role in T cell activation, cell growth, apoptosis, and angiogenesis, and its over-expression has been implicated in the pathogenesis of cardiomyopathy and stroke. However, the...
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Regulation of Inflammatory Repertoires and NF-kappaB Signal Transduction by DDB, an Active Compound from Schizandra Chinensis Baillon

Joo SS, Yoo YM, Won TJ, Kim MJ, Lee SG, Hwang KW, Lee DI

BACKGROUND: Chronic inflammation in the brain has known to be associated with the development of a various neurological diseases including dementia. In general, the characteristic of neuro-inflammation is the activated...
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Induction of Interleukin-8 Expression in Synovial Cell by Hepatitis C Virus Core Protein

Wang JS, Her W, Kim SY, Yoon SK

BACKGROUND: Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease that is characterized by invasive synovial hyperplasia, leading to progressive joint destruction. Recent studies have described that RA is...
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Granulocyte Colony Stimulating Factor (G-CSF) Attenuates 2,4,6-Trinitrobenzene Sulfonic Acid (TNBS)-induced Colitis in Mice

Choi EY, Jun CD, Oh JM, Kim YR, Lee ST, Kim SW

BACKGROUND: Granulocyte colony stimulating factor (G-CSF) is known as a cytokine central to the hematopoiesis of blood cells and to modulate their cellular functions. Besides granulocytes and their precursors, monocytes/macrophages...
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IL-2-enhanced NK Cell Cytotoxicity is Regulated by Adiponectin from Hypothalamo-pituitary-adrenal Axis

Kim K, Yang Y

BACKGROUND: The Hypothalamo-Pituitary-Adrenal (HPA) axis is an important regulator for the body's stress response. As a primary stress responsive system, HPA-axis secretes various neurotransmitters, hormones, and cytokines, which regulates the...
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Differences in Their Proliferation and Differentiation between B-1 and B-2 Cell

Yeo SG, Cha CI, Park DC

BACKGROUND: B cell subset has been divided into B-1 cells and B-2 cells. B-1 cells are found most prominently in the peritoneal cavity, as well as constituting a small proportion...
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