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The Analysis of Exercise on the Immune Responses

Kwak YS, Jin YW, Paik IY, Um SY

The immune response to any stimulus is complex, requiring coordinated action by several types of cells in a tightly regulated sequence. Thus, a physical stress such as exercise may act...
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Application of Apoptogenic Pretreatment to Enhance Anti-tumor Immunity of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)-secreting CT26 Tumor Cells

Jun DY, Jaffee EM, Kim YH

BACKGROUND: As an attempt to develop a strategy to improve the protective immune response to GM-CSF-secreting CT26 (GM-CSF/CT26) tumor vaccine, we have investigated whether the apoptogenic treatment of GM-CSF/CT26 prior...
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Cancer Vaccines

Son EW, In SW, Pyo S

Cancer vaccine is an active immunotherapy to stimulate the immune system to mount a response against the tumor specific antigen. Working as a stimulant to the body's own immune system,...
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The Expression of Galectin-3, a Beta-Galactoside Binding Protein, in Dendritic Cells

Kim MH, Joo HG

BACKGROUND: Dendritic cells (DCs) are the most potent APCs (antigen-presenting cells) and play a critical role in immune responses. Galectin-3 is a biological lectin with a beta-galactoside binding affinity. Recently,...
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A Combination of PG490 and Lipopolysaccharide Induce Apoptosis through Activation of Casapase-3 and Down- regulation of cIAP1 and XIAP in Human Astroglioma Cell

Lee TJ, Woo KJ, Park JW, Kwon TK

BACKGROUND: Malignant gliomas are the most common primary tumors in the central nervous system. METHODS: We investigated the combined effect of PG490 and LPS on the induction of the apoptotic...
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Opposite Roles of B7.1 and CD28 Costimulatory Molecules for Protective Immunity against HSV-2 Challenge in a gD DNA Vaccine Model

Weiner DB, Sin JI

BACKGROUND: Costimulation is a critical process in Ag-specific immune responses. Both B7.1 and CD28 molecules have been reported to stimulate T cell responses during antigen presentation. Therefore, we tested whether...
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Development of Tumor Screening ELISA kit by Using Novel Tumor Antigen, CM1

Kang JS, Kim D, Kim YI, Lee WJ, Chang KY

BACKGROUND: CM1 (centrocyte/-blast marker 1) is originally defined as a germinal center B cell marker. It is known that CM1 plays a critical role on B cell development in germinal...
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CD8+ T Cell-mediated Immunity Induced by Heterologous Prime-boost Vaccination Based on DNA Vaccine and Recombinant Vaccinia Virus Expressing Epitope

Park SO, Yoon HA, Aleyas AG, Lee JH, Chae JS, Eo SK

BACKGROUND: DNA vaccination represents an anticipated approach for the control of numerous infectious diseases. Used alone, however, DNA vaccine is weak immunogen inferior to viral vectors. In recent, heterologous prime-boost...
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Selective Expansion of TCR V beta 3+CD4+ T Cells in Collagen-induced Arthritis in DBA/1 Mice

Lee JS, Cho ML, Lee JE, Min SY, Yoon CH, Kim WU, Min JK, Park SH, Kim HY

BACKGROUND: Collagen-induced arthritis (CIA) in mice is animal model of autoimmune disease known as rheumatic arthritis in human. We investigated CII-specific CD4+ T cell receptor usage in CIA mice. METHODS:...
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