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Enhancement of Nitric Oxide Production by Corticotropin-releasing Hormone (CRH) in Murine Microglial Cells, BV2

Yang YH, Yang Y, Cho DH

BACKGROUND: Microglial cells, major immune effector cells in the central nervous system, become activated in neurodegenerative disorders. Activated microglial cells produce proinflammatory mediators such as nitric oxide (NO), tumor necrosis...
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Immune Tolerance in Murine Islet Transplantation Across HY Disparity

Choi SE, Park CG

BACKGROUND: Minor histocompatibility HY antigen, as a transplantation antigen, has been known to cause graft rejection in MHC (major histocompatibility complex) matched donor-recipient. The aim of our study is to...
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Dendritic Cell Based Cancer Immunotherapy: in vivo Study with Mouse Renal Cell Carcinoma Model

Lee H, Choi KM, Baek S, Lee HG, Jung CW

BACKGROUND: As a potent antigen presenting cell and a powerful inducer of antigen specific immunity, dendritic cells (DCs) are being considered as a promising anti-tumor therapeutic module. The expected therapeutic...
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The Effectiveness of IL-12 Administration and Fusion on Tumor Antigen Sensitization Methods for Dendritic Cells Derived from Patients with Myelogenous Leukemia

Kim KW, Park SY, Hong YS

BACKGROUND: Immunotherapy using dendritic cells (DC) loaded with tumor antigens may represent a potentially effective method for inducing antitumor immunity. We evaluated the effectiveness of DC-based antitumor immune response in...
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Adoptive Transfer of Colon Cancer Derived Peptide-specific CD8+ T Cells in HHD Mice

Jung HS, Ahn IS, Do HK, Lemonnier , Tirosh B, Tzehoval E, Vadai E, Eisenbach , Do MS

BACKGROUND: 1-8D gene is a member of human 1-8 interferon inducible gene family and is shown to be overexpressed in fresh colon cancer tissues. Three peptides 1-6, 3-5 and 3-7...
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Characterization of a Monoclonal Antibody Specific to Human Siah-1 Interacting Protein

Yoon SY, Joo JH, Kim JH, Kang HB, Kim JS, Lee Y, Kwon DH, Kim CN, Choe IS, Kim JW

BACKGROUND: A human orthologue of mouse S100A6-binding protein (CacyBP), Siah- 1-interacting protein (SIP) had been shown to be a component of novel ubiquitinylation pathway regulating beta-catenin degradation. The role of...
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Development of Human Antibody Inhibiting RNase H Activity of Polymerase of Hepatitis B Virus Using Phage Display Technique

Lee SR, Song EK, Jeong YJ, Lee YY, Kim IJ, Choi IH, Park SG

BACKGROUND: To develop a novel treatment strategy for hepatitis B virus infection, a major cause of liver chirosis and cancer, we aimed to make human monoclonal antibodies inhibiting RNase H...
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Isolation and Characterization of Human scFv Molecules Specific for Recombinant Human Heat Shock Protein (HSP) 70.1

Baek HJ, Lee JS, Seo JS, Cha SH

BACKGROUND: The heat shock proteins (HSPs) play an important role in cellular protection mechanisms against physical or chemical stresses. In this study scFv antibodies specific for human HSP70.1 were isolated...
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Transplantation Immunology from the Historical Perspective

Park CG

Transplantation would be the only way to cure the end-stage organ failure involving heart, lung, liver, kidney and pancreas. The replacement of the parts of the body damaged to lose...
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