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The Cell Cycle Regulatory Effects of High Dose 5-fluorouracil on Breast Cancer Cell Line

Jang JS, Yang JI, Chang SH, Lee WS, Lee JS, Ahn MJ, Park BK

BACKGROUND: Chemotherapy with 5-fluorouracil (5-FU) has been one of the mainstay in breast cancer treatment. The effects of high dose 5-FU on cell cycle regulation were studied in breast caner...
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Increased Expression of Fas Antigen and Apoptosis in Aplastic Anemia Bone Marrow Cells

Won JH, Lee NS, Kim SJ, Cheong HJ, Lee KT, Park SK, Baick SH, Kim SI, Hong DS, Park HS

BACKGROUND: Clinical observations and laboratory studies have supported an immune basis for most acquired aplastic anemias, with the majority of patients responding to immunosuppressive therapy. Fas, a member of the...
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Autologous Peripheral Blood Stem Cell Transplantation Using G-CSF Combined Conditioning in AML Patients

Kim BS, Kook H, Hwang TJ, Choi CW, Kim JS

BACKGROUND: The possibility that G-CSF recruits leukemic cells from the G0 to S phase, which may lead to a greater susceptibility to cytotoxic drugs, such as ara-C, has been presented...
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Protective Effects on A2Kb Transgenic Mice That Were Immunized with Hepatitis B Virus X Antigen Peptides by the Activation of CD8? T Cells; XEP-3 Specific CTL Responses in the in vitro Culture

Hwang YK, Kim HI, Kim NK, Park JM, Cheong HS

BACKGROUND: Viral antigens presented on the cell surface in association with MHC class I molecules are recognized by CD8+ T cells. MHC restricted peptides are important in eliciting cellular immune...
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Characterization of CTLA-4 Antigen Expression Identification of Molecules Composing Intracellular CTLA-4 Multiprotein Complex

Rhim DC, Chung YH

BACKGROUND: CTLA-4 (Cytotoxic T Lymphocyte associated Antigen 4, CD152) has been known as a homologue of CD28, an accessory molecule providing a key costimulatory signal for successful antigen-driven activations of...
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Effects of Antioxidant on the Hypoxia-induced Expression of ICAM-1 in Cultured Human Synovial Fibroblasts

Kim JR, Yoo WH

BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia and joint destruction. The synovial fibroblasts express cell adhesion molecules and have a role in adhesive interation...
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Salvia miltiorrhiza Inhibits Tumor Cell Growth in Association with Rb Dephosphorylation through Up-regulation of p21 Via a p53-dependent Pathway

Chung J, Chang JE, Son YH, Park HR, Lim SH, Oh YH, Lee MY, Park YM

BACKGROUND: Salvia miltiorrhiza (SM), a traditional oriental medicine, has been reported to have anti-tumor properties, but its exact mechanism remains to be elucidated. In this study, we investigated several of...
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Effect of Interleukin-10 on Lipopolysaccahride/Interferon-gamma- Induced Chemokine Mig Gene Expression

Choi JH, Jin JS, Park HS, Kim SK, Lee JY, Kim HS

Interferon-gamma (IFN-gamma) is well known as a potent inducer in monokine induced by IFN-gamma (Mig) mRNA expression. Although lipopolysaccharide (LPS) alone is weakly effective on Mig mRNA expression. the stimulation...
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Allicin Reduces Adhesion Molecules and NO Production Induced by gamma irradiation in Human Endothelial Cells

Son EW, Cho CK, Pyo SN

BACKGROUND: Inflammation is a frequent reaction following therapeutic irradiation. Since the upregulation of adhesion molecules on endothelial cell surface is known to be associated with inflammation, the expression of adhesion...
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Perspectives of AIDS Vaccine Development T Cell-based Vaccine

Sung YC

Estimated number of adults and children newly infected with HIV-1 during 2001 alone is 5 million in total. An effective vaccine, in addition to education & public health approaches, has...
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