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Immunomodulating and Antitumor Activities of Exo-secretion from Phellinus linteus

Maeng EH, Lee YT, Cho KB, Hong SH

BACKGROUND: The chemical characteristics of the exo-secretion from Phellinus linteus (referred to as exo-secretion) including the compositions of amino acids and monosaccharides were investigated. In addition, cytotoxicity of the exo-secretion...
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The Effect of Chemical Sympathectomy on Moxibustion-Induced Immunomodulation in the Rat Spleen

Han JB, Oh SD, Lee KS, Choi KS, Cho YW, Ahn HJ, Bae HS, Min BI

BACKGROUND: To investigate the role of sympathetic nervous system (SNS) in moxibustion-induced immunomodulation, the effects of chemical sympathectomy on moxibustion-induced changes in splenic NK cell cytotoxicity, T and B cell...
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Role of N-terminal Hydrophilic Amino Acids in Molecular Translocation of CTLA-4 to Cell Surface

Han JW, Lee HJ, Kim JM, Choi EY, Chung HJ, Lim SB, Choi JW, Chung YH

BACKGROUND: This study was aimed to differentiate two forms of CTLA-4 (CD152) in activated peripheral blood lymphocyte and clarify the mechanism how cytoplasmic form of this molecule is targeted to...
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The Effects of Swimming Training on Lymphocyte Proliferation and ROS Production in Spleen Lymphocytes of BALB/c Mice

Kwak YS, Park JH, Kim SJ, Jang YS, Lee BK

BACKGROUND: Aerobic training can be defined as any physical exercise that increases the heart rate and enhances the body's intake of oxygen long enough to benefit the condition of body....
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Isolation of Human scFv Antibodies Specific for House Dust Mite Antigens from an Asthma Patient by Using a Phage Display Library

Jung WL, Lee HK, Yong TS, Cha SH

BACKGROUND: In order to characterize human antibodies with specificity for mite allergens at the molecular level, a scFv phage display library was constructed using peripheral blood mononuclear lymphocytes from an...
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High Frequencies of the CCR2b-64I and SDF1-3'A Mutations with HIV Infection in Koreans

Choi BS, Cha SH, Kim SS, Park YK, Lee JS

BACKGROUND: Host genetic polymorphisms in the HIV-1 co-receptor CCR5 and CCR2b and SDF-1, ligand for co-receptor CXCR4, have been known to be associated with the resistance of HIV infection and/or...
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Evidence for V(H) Gene Replacement in Human Fetal B Cells

Lee JS, Cho YJ, Lipsky PE

BACKGROUND: In contrast to evidences of Ig H chain receptor editing in transformed cell lines and transgenic mouse models, there has been no direct evidence that this phenomenon occurs in...
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Identification of SAP as a CTLA-4 Binding Molecule: a Role of SAP in CTLA-4 Signaling Proposed

Lee KM

BACKGROUND: The precise mechanism by which CTLA-4 regulates T cell immune responses is still not fully understood. Previously we proposed that CTLA-4 could downregulate T cell function by modulating a...
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Immunologic Mechanism of Experimental and Therapeutic Ultraviolet B Responses

Lew W

The immunological mechanism of the responses to ultraviolet (UV) B radiation in mouse models were investigated by the suppression of contact hypersensitivity (CHS) and delayed type hypersensitivity (DTH), and susceptibility...
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