- Psoriasis as a T-cell-mediated Immunologic Disease
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Lew W
- KMID: 1974516
- Immune Netw.
- 2002 Dec;2(4):189-194.
- doi: 10.4110/in.2002.2.4.189
Although the exact mechanism responsible for the pathogenesis of psoriasis is unclear, interferon-gamma producing type 1 T cells have been reported to play a significant role. Infiltrating activated type 1... -
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- Telomerase: Key to Mortal or Immortal Road
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Yang EY, Sung YH, Lee HW
- KMID: 1974515
- Immune Netw.
- 2002 Dec;2(4):183-188.
- doi: 10.4110/in.2002.2.4.183
Gradual attrition of telomere to a critical short length elicits successive cellular response of cellular senescence and crisis. Cancer cells evade this process by maintaining functional telomeres via one of... -
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- Serum Levels of Type 2 Chemokines in Lepromatous Leprosy Patients
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Lew W, Nakamura K, Tada Y, Kwahck H, Chang SK, Tamaki K
- KMID: 1974521
- Immune Netw.
- 2002 Dec;2(4):223-226.
- doi: 10.4110/in.2002.2.4.223
BACKGROUND: The type 2 deviated immunological state is predominant in lepromatous leprosy. Erythema nodosum leprosum (ENL) is an immune-complex mediated reaction that typically occurs in lepromatous leprosy. To date, the... -
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- Family Study of TAP Gene Polymorphism and HLA-TAP Haplotypes in Koreans
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Whang DH, Park MH
- KMID: 1974525
- Immune Netw.
- 2002 Dec;2(4):248-255.
- doi: 10.4110/in.2002.2.4.248
BACKGROUND: TAP1 and TAP2 are two ABC transporter genes located within the class II region of the human MHC. Their protein products form a heterodimer whose function is to transport... -
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- The Differential Staging of Murine Thymic Lymphoma Cell Lines, Scid.adh, R1.1 and EL-4
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Chae JS, Kim HJ, Park WS, Bae Y, Jung KC
- KMID: 1974520
- Immune Netw.
- 2002 Dec;2(4):217-222.
- doi: 10.4110/in.2002.2.4.217
BACKGROUND: Scid.adh is a recently developed murine thymic lymphoma cell line, which has been used as in vitro model for the study of double negative stage III thymocytes. In this... -
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- Identification of Functionally Different Rat IgE in RBL-2H3 Exocytosis
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Kim JS, Cho S, Joo KH, Lee JS, Conrad DH, Cho SW
- KMID: 1974517
- Immune Netw.
- 2002 Dec;2(4):195-201.
- doi: 10.4110/in.2002.2.4.195
BACKGROUND: IgE is closely related to the development of allergies. However, the poor relationship between the specific IgE level and the severity of allergic diseases suggests the possibility of functionally... -
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- The Association of HLA-DRB1 and DQB1 Alleles and a Study of Anticardiolipin Antibody and Anti-beta2 Glycoprotein I Antibody in Korean SLE Patients
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Lee SG, Cha HS, Yang YS
- KMID: 1974522
- Immune Netw.
- 2002 Dec;2(4):227-232.
- doi: 10.4110/in.2002.2.4.227
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by diverse clinical manifestations and autoantibody production, which is known to be strongly influenced by genetic factors. Previous studies... -
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- Isolation of Mouse Ig Heavy and Light Chain Genomic DNA Clones, and Construction of Gene Knockout Vector for the Generation of Humanized Xenomouse
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Lee HK, Cha SH
- KMID: 1974523
- Immune Netw.
- 2002 Dec;2(4):233-241.
- doi: 10.4110/in.2002.2.4.233
BACKGROUND: Monoclonal antibodies (mAb) of rodent origin are produced with ease by hybridoma fusion technique, and have been successfully used as therapeutic reagents for humans after humanization by genetic engineering.... -
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- Production of Plasma Leptin and Expression of Interferon-gamma Inducible Protein-10 (IP-10), Monokine Induced by Interferon-gamma (Mig) and Interleukin-8 (IL-8) mRNA in Kawasaki Disease
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Lee YH, Kim WD, Kim HS
- KMID: 1974518
- Immune Netw.
- 2002 Dec;2(4):202-207.
- doi: 10.4110/in.2002.2.4.202
BACKGROUND: Kawasaki disease is an acute febrile illness with systemic vasculitis which primarily affects children, We examined the production of leptin in plasma and gene expressions of CXC chemokines in... -
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- Suppressed DNA Repair Mechanisms in Rheumatoid Arthritis
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Lee SH, Firestein
- KMID: 1974519
- Immune Netw.
- 2002 Dec;2(4):208-216.
- doi: 10.4110/in.2002.2.4.208
BACKGROUND: Reactive oxygen and nitrogen are produced by rheumatoid arthritis (RA) synovial tissue and can induce mutations in key genes. Normally, this process is prevented by a DNA mismatch repair... -
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- Polymorphisms in the TNF-alpha Gene and Extended HLA and TNF-alpha Haplotypes in Koreans
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Park YJ, Park HJ, Park MH
- KMID: 1974524
- Immune Netw.
- 2002 Dec;2(4):242-247.
- doi: 10.4110/in.2002.2.4.242
BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is known to play an important role in various conditions such as inflammation, autoimmunity, apoptosis, insulin resistance and sleep induction. Five single nucleotide polymorphisms (SNPs)... -
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