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The Effect of alpha2 Adrenoceptors and Imidazoline Receptors on the Mechanical Allodynia in Rats with Nerve Ligation Injury

Hwang JH, Kim YK, Park JY, Jun HJ

BACKGROUND: Clonidine, an alpha2 adrenoceptor agonist, has been known to have an antiallodynic effect in many animal and human studies. Clonidine, however, acts on imidazoline receptors as well as...
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Effects of Intra-articular Injection of Agmatine and Clonidine into the Knee Joint Cavity on the Induction and Maintenance of Arthritic Pain in Rats

Lee MJ, Shim HS, Seol GH, Kim PJ, Han SH, Yee J, Kim C, Lee KC, Kim HY, Min SS

BACKGROUND: Previous studies suggest that systemic administration of agmatine, endogenous ligand for imidazoline receptors has anti-hypernociceptive effects in experimental animal. However the peripheral effects of agmatine on inflammatory pain have...
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The Effect of Brimonidine Premedication on the Sympathetic Nervous System during Ketamine Anesthesia in the Ratv

Hwang KS, Choi Y, Lee SY, Lee YS, Lee YK, Jun HJ, Park SE, Han SM

BACKGROUND: The use of ketamine as the sole anesthetic induces marked central sympathetic stimulation, causing an increase of heart rate and blood pressure. alpha2-receptor agonist has been demonstrated to attenuate...
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