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Degradation of the Transcription Factors NF-kappaB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells

Kim KA, Min A, Lee YA, Shin MH

Entamoeba histolytica is a tissue-invasive protozoan parasite causing dysentery in humans. During infection of colonic tissues, amoebic trophozoites are able to kill host cells via apoptosis or necrosis, both of...
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Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappa B activation

Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH

  • KMID: 1094655
  • Exp Mol Med.
  • 2007 Apr;39(2):149-159.
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpenicillamine-induced apoptotic cell death via the inhibition of mitochondrial membrane potential disruption and cytochrome c release in RINm5F (RIN) rat insulinoma...
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Anti-inflammatory Mechanism of Lactobacillus rhamnosus GG in Lipopolysaccharide-stimulated HT-29 Cell

Lee SK, Yang KM, Cheon JH, Kim TI, Kim WH

BACKGROUND/AIMS: Probiotics are live non-pathogenic organisms that belong to the resident microflora, and confer health benefits by multiple mechanisms. Lactobacillus rhamnosus GG (LGG) is one of the probiotic bacteria that...
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Toll-Like Receptor 4 Signaling is Involved in IgA-Stimulated Mesangial Cell Activation

Lim BJ, Lee D, Hong SW, Jeong HJ

PURPOSE: Deposition of polymeric IgA1 in the kidney mesangium is the hallmark of IgA nephropathy, but the molecular mechanisms of IgA-mediated mesangial responses and inflammatory injuries remain poorly understood. We...
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