Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

more+
SELECT FILTER
 
Close

PUBLICATION DATE

47 results
Display

Treatment of Diabetic Kidney Disease: Current and Future

Yamazaki T, Mimura I, Tanaka T, Nangaku M

Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However, only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD. In 2019, sodium-glucose cotransporter 2 (SGLT2)...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Proangiogenic Hypoxia-Mimicking Agents Attenuate Osteogenic Potential of Adipose Stem/Stromal Cells

Abu-Shahba AG, Gebraad A, Kaur S, Paananen RO, Peltoniemi H, Seppa¨nen-Kaijansinkko R, Mannerstro¨m B

BACKGROUND: Insufficient vascularization hampers bone tissue engineering strategies for reconstructing large bonedefects. Delivery of prolyl-hydroxylase inhibitors (PHIs) is an interesting approach to upregulate vascular endothelialgrowth factor (VEGF) by mimicking hypoxic...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bacillus clausii, a Foreshore-Derived Probiotic, Attenuates Allergic Airway Inflammation Through Downregulation of Hypoxia Signaling

Park H, Jung AY, Chang CS, Kim YH

Background and Objectives: The immunomodulatory effects and mechanism of probiotics in allergic airway disease are largely unknown. We studied whether Bacillus clausii (BC), a probiotic derived from mudflats, had anti-allergic...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The Role of a Neurovascular Signaling Pathway Involving Hypoxia-Inducible Factor and Notch in the Function of the Central Nervous System

Kim S, Lee M, Choi YK

In the neurovascular unit, the neuronal and vascular systems communicate with each other. O2 and nutrients, reaching endothelial cells (ECs) through the blood stream, spread into neighboring cells, such as...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging

Wang Y, Zhang X, Wang B, Xie Y, Wang Y, Jiang X, Wang R, Ren K

OBJECTIVE: To examine the potential of intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) magnetic resonance imaging for detecting renal changes after iodinated contrast-induced acute kidney injury (CI-AKI) development...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Role of HIF1α Regulatory Factors in Stem Cells

Lee HJ, Jung YH, Choi GE, Kim JS, Chae CW, Han HJ

Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that induces the transcription of genes involved in the metabolism and behavior of stem cells. HIF1-mediated adaptation to hypoxia is required...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The role of oxidative stress and hypoxia in renal disease

Honda T, Hirakawa Y, Nangaku M

Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are constantly released during mitochondrial oxygen consumption for energy production. Any imbalance between ROS production and its scavenger system...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia

Jeon GW, Sheldon RA, Ferriero D

BACKGROUND: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells

Jin CE, Lee JH, Kim GJ, Lee TH

OBJECTIVES: Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/SMAD Family Member 3 Pathway to Promote Breast Cancer Progression

Peng J, Wang X, Ran L, Song J, Luo R, Wang Y

PURPOSE: The transforming growth factor β1 (TGF-β1)/SMAD family member 3 (SMAD3) pathway, and hypoxia-inducible factor 1α (HIF-1α) are two key players in various types of malignancies including breast cancer. The...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effects of estradiol on HIF-1α expression and trophoblast differentiation in first trimester villous explant cultures

Cho GJ, Lee LH, Lee B, Lee J, Ahn KH, Hong SC, Kim HJ, Oh MJ

OBJECTIVE: The purpose of this study was to investigate the effects of estradiol on the expression of hypoxia-inducible factor (HIF)-1α and the differentiation of trophoblasts in human first trimester villous...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Tibial dyschondroplasia is closely related to suppression of expression of hypoxia-inducible factors 1α, 2α, and 3α in chickens

Huang S, Rehman MU, Qiu G, Luo H, Iqbal MK, Zhang H, Mehmood K, Li J

Tibial dyschondroplasia (TD) cases has not been reported in Tibetan chickens (TBCs), but it is commonly seen in commercial broilers characterized by lameness. The underlying mechanism remains unclear. Hypoxia-inducible factors...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy

Yu T, Tang B, Sun X

Hypoxia is frequently observed in solid tumors and also one of the major obstacles for effective cancer therapies. Cancer cells take advantage of their ability to adapt hypoxia to initiate...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effects of Histone Deacetylase Inhibitor (Valproic Acid) on the Expression of Hypoxia-inducible Factor-1 Alpha in Human Retinal Müller Cells

Kim YJ, Park SJ, Kim NR, Chin HS

PURPOSE: To evaluate the effects of valproic acid (VPA), a histone deacetylase inhibitor (HDACI), on the expression of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in human...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1alpha in a Rat Model of Bronchopulmonary Dysplasia

Choi CW, Lee J, Lee HJ, Park HS, Chun YS, Kim BI

Fetal lung development normally occurs in a hypoxic environment. Hypoxia-inducible factor (HIF)-1alpha is robustly induced under hypoxia and transactivates many genes that are essential for fetal development. Most preterm infants...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Controlled Gene Expression System under Hypoxia Conditions

Yun Y, Ha Y

  • KMID: 2505508
  • Korean J Aerosp Environ Med.
  • 2015 Dec;25(3):85-90.
Purpose: To understand the phenomenon of gene expression under hypoxia conditions, hypoxia-inducible vector system was constructed. Hypoxia-inducible enhancer and 3’ untranslated region was responsible to overexpress so that regulates gene...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Resveratrol Inhibits Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Pathological Neovascularization

Lee CS, Choi EY, Lee SC, Koh HJ, Lee JH, Chung JH

PURPOSE: To investigate the effects of resveratrol on the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human adult retinal pigment epithelial (ARPE-19) cells, and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool

Kim J, So D, Shin HW, Chun YS, Park JW

Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells

Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ

PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas

Jha MK, Suk K

Metabolic aberrations in the form of altered flux through key metabolic pathways are the major hallmarks of several life-threatening malignancies including malignant gliomas. These adaptations play an important role in...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr