- Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
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Han S, Huh J, Kim W, Jeong S, Min DS, Jung Y
- KMID: 2155391
- Exp Mol Med.
- 2014 Dec;46(12):e126.
- doi: 10.1038/emm.2014.86
Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is... -
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- Phosphodiesterase Inhibitor Improves Renal Tubulointerstitial Hypoxia of the Diabetic Rat Kidney
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Sun HK, Lee YM, Han KH, Kim HS, Ahn SH, Han SY
- KMID: 1776543
- Korean J Intern Med.
- 2012 Jun;27(2):163-170.
- doi: 10.3904/kjim.2012.27.2.163
BACKGROUND/AIMS: Renal hypoxia is involved in the pathogenesis of diabetic nephropathy. Pentoxifyllin (PTX), a nonselective phosphodiesterase inhibitor, is used to attenuate peripheral vascular diseases. To determine whether PTX can improve... -
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