- Phospholipase D2 promotes degradation of hypoxia-inducible factor-1alpha independent of lipase activity
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Park MH, Bae SS, Choi KY, Min DS
- KMID: 2359883
- Exp Mol Med.
- 2015 Nov;47(11):e196.
- doi: 10.1038/emm.2015.87
Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension. The stability of HIF-1alpha protein... -
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- Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1alpha in a Rat Model of Bronchopulmonary Dysplasia
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Choi CW, Lee J, Lee HJ, Park HS, Chun YS, Kim BI
- KMID: 2344155
- J Korean Med Sci.
- 2015 Sep;30(9):1295-1301.
- doi: 10.3346/jkms.2015.30.9.1295
Fetal lung development normally occurs in a hypoxic environment. Hypoxia-inducible factor (HIF)-1alpha is robustly induced under hypoxia and transactivates many genes that are essential for fetal development. Most preterm infants... -
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- Hypoxic Regulation of VEGF, HIF-1 (alpha) in Coronary Collaterals Development
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Sung KC, Kim KS, Lee S
- KMID: 1115253
- Korean J Intern Med.
- 2005 Dec;20(4):295-302.
- doi: 10.3904/kjim.2005.20.4.295
BACKGROUND: The interindividual variability for the development of collaterals in coronary artery disease is dependent on the hypoxic induction level of VEGF. To determine whether the hypoxic induction of VEGF... -
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- A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha
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Lee KS, Kim SR, Park HS, Park SJ, Min KH, Lee KY, Choe YH, Hong SH, Han HJ, Lee YR, Kim JS, Atlas D, Lee YC
- KMID: 1091070
- Exp Mol Med.
- 2007 Dec;39(6):756-768.
Reactive oxygen species (ROS) play an important role in the pathogenesis of airway inflammation and hyperresponsiveness. Recent studies have demonstrated that antioxidants are able to reduce airway inflammation and hyperreactivity... -
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