- Altered Intestinal Permeability and Drug Repositioning in a Post-operative Ileus Guinea Pig Model
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Kim YM, Hussain Z, Lee YJ, Park H
- KMID: 2521171
- J Neurogastroenterol Motil.
- 2021 Oct;27(4):639-649.
- doi: 10.5056/jnm21018
Background/Aims The aim of this study is to identify the alteration in intestinal permeability with regard to the development of post-operative ileus (POI). Moreover, we investigated drug repositioning in the treatment of... -
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- Inflammation and Impaired Gut Physiology in Post-operative Ileus: Mechanisms and the Treatment Options
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Hussain Z, Park H
- KMID: 2534311
- J Neurogastroenterol Motil.
- 2022 Oct;28(4):517-530.
- doi: 10.5056/jnm22100
Post-operative ileus (POI) is the transient cessation of coordinated gastrointestinal motility after abdominal surgical intervention. It decreases quality of life, prolongs length of hospital stay, and increases socioeconomic costs. The... -
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- The Effect of DA-9701 in Opioid-induced Bowel Dysfunction of Guinea Pig
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Hussain Z, Rhee KW, Lee YJ, Park H
- KMID: 2327959
- J Neurogastroenterol Motil.
- 2016 Jul;22(3):529-538.
- doi: 10.5056/jnm15194
BACKGROUND/AIMS: Opioid induced bowel dysfunction (OIBD) is associated with decreased gastrointestinal (GI) propulsive activity due to intake of opioid analgesics. DA-9701, a novel prokinetic agent formulated with Pharbitis Semen and... -
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- The Effect of Trimebutine on the Overlap Syndrome Model of Guinea Pigs
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Hussain Z, Jung DH, Lee YJ, Park H
- KMID: 2422856
- J Neurogastroenterol Motil.
- 2018 Oct;24(4):669-675.
- doi: 10.5056/jnm18049
BACKGROUND/AIMS: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) disorders and these patients frequently overlap. Trimebutine has been known to be effective in controlling FD co-existing... -
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- Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus
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Lee YJ, Hussain Z, Huh CW, Lee YJ, Park H
- KMID: 2417282
- J Neurogastroenterol Motil.
- 2018 Jan;24(1):147-158.
- doi: 10.5056/jnm17012
BACKGROUND/AIMS: Postoperative ileus (POI) is characterized by impaired propulsive function of the gastrointestinal tract after surgery. Although inflammation is considered to be an important pathogenesis of POI, significant data are... -
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- The Effect of Peripheral CRF Peptide and Water Avoidance Stress on Colonic and Gastric Transit in Guinea Pigs
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Hussain Z, Kim HW, Huh CW, Lee YJ, Park H
- KMID: 2419097
- Yonsei Med J.
- 2017 Jul;58(4):872-877.
- doi: 10.3349/ymj.2017.58.4.872
Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) diseases; however, there is frequent overlap between FD and IBS patients. Emerging evidence links the activation of corticotropin... -
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