- The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells
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Jin KL, Park JY, Noh EJ, Hoe KL, Lee JH, Kim JH, Nam JH
- KMID: 2173551
- J Gynecol Oncol.
- 2010 Dec;21(4):262-268.
- doi: 10.3802/jgo.2010.21.4.262
OBJECTIVE: To investigate the combined effects of cisplatin and the histone deacetylase (HDAC) inhibitors suberoylanilide hydroxamic acid (SAHA) or sirtinol on HeLa cells and assess the mechanism underlying HDAC inhibitor-cisplatin... -
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- 8-Methoxypsoralen Induces Apoptosis by Upregulating p53 and Inhibits Metastasis by Downregulating MMP-2 and MMP-9 in Human Gastric Cancer Cells
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Choi EK, Kim HD, Park EJ, Song SY, Phan TT, Nam M, Kim M, Kim DU, Hoe KL
- KMID: 2539591
- Biomol Ther.
- 2023 Mar;31(2):219-226.
- doi: 10.4062/biomolther.2023.004
Furanocoumarin 8-methoxypsoralen (8-MOP) is the parent compound that naturally occurs in traditional medicinal plants used historically. 8-MOP has been employed as a photochemotherapeutic component of Psoralen + Ultraviolet A (PUVA)... -
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- Econazole Induces p53-Dependent Apoptosis and Decreases Metastasis Ability in Gastric Cancer Cells
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Choi EK, Park EJ, Phan TT, Kim HD, Hoe KL, Kim DU
- KMID: 2503477
- Biomol Ther.
- 2020 Jul;28(4):370-379.
- doi: 10.4062/biomolther.2019.201
Econazole, a potent broad-spectrum antifungal agent and a Ca2+ channel antagonist, induces cytotoxicity in leukemia cells and is used for the treatment of skin infections. However, little is known about... -
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- Activation of epidermal growth factor receptor is responsible for pervanadate-induced phospholipase D activation
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Kim YR, Cha HY, Lim K, Hwang BD, Hoe KL, Namgung U, Park SK
- KMID: 1097260
- Exp Mol Med.
- 2003 Apr;35(2):118-124.
Pervanadate, a complex of vanadate and H2O2, has an insulin mimetic effect, and acts as an inhibitor of protein tyrosine phosphatase. Pervanadate-induced phospholipase D (PLD) activation is known to be... -
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- Optimization of a microarray for fission yeast
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Kim DU, Lee M, Han S, Nam M, Lee S, Lee J, Woo J, Kim D, Hoe KL
- KMID: 2462042
- Genomics Inform.
- 2019 Sep;17(3):e28.
- doi: 10.5808/GI.2019.17.3.e28
Bar-code (tag) microarrays of yeast gene-deletion collections facilitate the systematic identification of genes required for growth in any condition of interest. Anti-sense strands of amplified bar-codes hybridize with ~10,000 (5,000... -
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- Systematic Target Screening Revealed That Tif302 Could Be an OffTarget of the Antifungal Terbinafine in Fission Yeast
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Lee S, Nam M, Lee AR, Lee J, Woo J, Kang NS, Balupuri A, Lee M, Kim SY, Ro H, Choi YW, Kim DU, Hoe KL
- KMID: 2513492
- Biomol Ther.
- 2021 Mar;29(2):234-247.
- doi: 10.4062/biomolther.2020.166
We used a heterozygous gene deletion library of fission yeasts comprising all essential and non-essential genes for a microarray screening of target genes of the antifungal terbinafine, which inhibits ergosterol... -
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- Mutation Analysis of Synthetic DNA Barcodes in a Fission Yeast Gene Deletion Library by Sanger Sequencing
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Lee M, Choi SJ, Han S, Nam M, Kim D, Kim DU, Hoe KL
- KMID: 2422818
- Genomics Inform.
- 2018 Jun;16(2):22-29.
- doi: 10.5808/GI.2018.16.2.22
Incorporation of unique barcodes into fission yeast gene deletion collections has enabled the identification of gene functions by growth fitness analysis. For fine tuning, it is important to examine barcode... -
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- Knockdown of vps54 aggravates tamoxifen-induced cytotoxicity in fission yeast
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Lee S, Nam M, Lee AR, Baek ST, Kim MJ, Kim JS, Kong AH, Lee M, Lee SJ, Kim SY, Kim DU, Hoe KL
- KMID: 2524330
- Genomics Inform.
- 2021 Dec;19(4):e39.
- doi: 10.5808/gi.21049
Tamoxifen (TAM) is an anticancer drug used to treat estrogen receptor (ER)‒positive breast cancer. However, its ER-independent cytotoxic and antifungal activities have prompted debates on its mechanism of action. To... -
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- Transactivation of bad by vorinostat-induced acetylated p53 enhances doxorubicin-induced cytotoxicity in cervical cancer cells
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Lee SJ, Hwang SO, Noh EJ, Kim DU, Nam M, Kim JH, Nam JH, Hoe KL
- KMID: 2155341
- Exp Mol Med.
- 2014 Feb;46(2):e76.
- doi: 10.1038/emm.2013.149
Vorinostat (VOR) has been reported to enhance the cytotoxic effects of doxorubicin (DOX) with fewer side effects because of the lower DOX dosage in breast cancer cells. In this study,... -
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- Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs
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Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S
- KMID: 2440020
- Exp Mol Med.
- 2018 Feb;50(2):e438.
- doi: 10.1038/emm.2017.254
Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that... -
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- NADPH oxidase activation contributes to native low-density lipoprotein-induced proliferation of human aortic smooth muscle cells
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Park IH, Hwang HM, Jeon BH, Kwon HJ, Hoe KL, Kim YM, Ryoo S
- KMID: 2155422
- Exp Mol Med.
- 2015 Jun;47(6):e168.
- doi: 10.1038/emm.2015.30
Elevated plasma concentration of native low-density lipoprotein (nLDL) is associated with vascular smooth muscle cell (VSMC) activation and cardiovascular disease. We investigated the mechanisms of superoxide generation and its contribution... -
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- Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation
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Nguyen MC, Park JT, Jeon YG, Jeon BH, Hoe KL, Kim YM, Lim HK, Ryoo S
- KMID: 2427149
- Yonsei Med J.
- 2016 Nov;57(6):1329-1338.
- doi: 10.3349/ymj.2016.57.6.1329
PURPOSE: Peroxynitrite plays a critical role in vascular pathophysiology by increasing arginase activity and decreasing endothelial nitric oxide synthase (eNOS) activity. Therefore, the aims of this study were to investigate... -
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- Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation
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Koo BH, Yi BG, Wang WK, Ko IY, Hoe KL, Kwon YG, Won MH, Kim YM, Lim HK, Ryoo S
- KMID: 2407859
- Yonsei Med J.
- 2018 May;59(3):366-375.
- doi: 10.3349/ymj.2018.59.3.366
PURPOSE: Vascular smooth muscle cell (VSMC) proliferation induced by native low-density lipoprotein (nLDL) stimulation is dependent on superoxide production from activated NADPH oxidase. The present study aimed to investigate whether... -
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