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Rac-mediated actin remodeling and myosin II are involved in KATP channel trafficking in pancreatic beta-cells

Han YE, Lim A, Park SH, Chang S, Lee SH, Ho WK

AMP-activated protein kinase (AMPK) is a metabolic sensor activated during metabolic stress and it regulates various enzymes and cellular processes to maintain metabolic homeostasis. We previously reported that activation of...
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Selective Cytotoxic Mechanism of Homocysteine to Motor Neuronal Cells Expressing the Mutant Cu,Zn-superoxide Dismutase

Sung JJ, Kim HJ, Kim SM, Min JH, Hong YH, Park KS, Kim M, Lee SH, Ho WK, Lee KW

  • KMID: 1957679
  • J Korean Neurol Assoc.
  • 2006 Feb;24(1):66-75.
BACKGROUND: Mutations in Cu, Zn-superoxide dismutase (SOD1) cause about 20% of familial amyotrophic lateral sclerosis (FALS) cases. The mechanism of late-onset disease manifestation despite the innate mutation has no clear...
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Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity in Rat Atrial Myocytes

Youm JB, Jo SH, Leem CH, Ho WK, Earm YE

  • KMID: 1517035
  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):33-41.
We developed a cardiac cell model to explain the phenomenon of mechano-electric feedback (MEF), based on the experimental data with rat atrial myocytes. It incorporated the activity of ion channels,...
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Two Components of Voltage Dependent Outward K+ Current in Isolated Human Atrial Myocytes

Nam GB, Ho WK

BACKGROUND: The cardiac electrophysiological characteristics differ significantly among mammalian species or among various disease processes. However, difficulties in the procedures for harvesting and isolating tissue have precluded studies using human...
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Modulation of L-type Ca2+ channel currents by various protein kinase activators and inhibitors in rat clonal pituitary GH3 cell line

Bae YM, Baek HJ, Cho HN, Earm YE, Ho WK

  • KMID: 2285234
  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):139-146.
L-type Ca2+ channels play an important role in regulating cytosolic Ca2+ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated...
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The role of K+ channels on spontaneous action potential in rat clonal pituitary GH3 cell line

Rhim H, Baek HJ, Ho WK, Earm YE

  • KMID: 1982593
  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):81-90.
The types of K+ channel which determine the pattern of spontaneous action potential (SAP) were investigated using whole-cell variation of patch clamp techniques under current- and voltage-clamp recording conditions in rat clonal pituitary...
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Effect of propofol, an intravenous anesthetic agent, on KATP channels of pancreatic beta-cells in rats

Park EJ, Song DK, Cheun JK, Bae JI, Ho WK, Earm YE

  • KMID: 1580632
  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):25-31.
ATP-sensitive potassium channels (KATP channels) play an important role in insulin secretion from pancreatic beta cells. We have investigated the effect of propofol on KATP channels in cultured single pancreatic beta cells of...
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The effects of intracellular monocarboxylates on the ATP-sensitive potassium channels in rabbit ventricular myocytes

Kim N, Han J, Kim YE, Ho WK, Earm YE

  • KMID: 2071538
  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):581-589.
A regulating mechanism of the ATP-sensitive potassium channels (KATP channels) is yet to fully explained. This study was carried out to investigate the effects of intracellular application of monocarboxylates (acetate, formate, lactate, and...
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Reduced dihydroxyacetone sensitivity and normal sensitivity to glyceraldehyde and oxidizing agent of ATP-sensitive K+ channels of pancreatic beta cells in NIDDM rats

Song DK, Park WK, Bae JH, Park MK, Kim SJ, Ho WK, Earm YE

The inhibition of ATP-sensitive K+(KATP) channels in pancreatic beta cells is a key step of insulin secretion induced by glucose. Glucose-induced insulin secretion from the beta cells is selectively...
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Effect of metabolic inhibition on inward rectifier K current in single rabbit ventricular myocytes

Chung YJ, Ho WK, Earm YE

  • KMID: 2285192
  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):741-748.
In the present study, we have investigated the effect of metabolic inhibition on the inward rectifer K current (IK1). Using whole cell patch clamp technique we applied voltage ramp from +80 mV...
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Effects of cyclic-GMP on hyperpolarization-activated inward current (I|f) in sino-atrial node cells of rabbit

Shin Y, Ho WK, Earm YE

  • KMID: 2285191
  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):731-739.
The aim of present study is to investigate the effects of cGMP on hyperpolarization activated inward current (If), pacemaker current of the heart, in rabbit sino-atrial node cells using the whole-cell patch clamp...
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A preliminary observation on watery content of small intestine in Metagonimus yokogawai infected dog

Cho SY, Kim SI, Earm YE, Ho WK

The intestinal contents of a dog infected with 49,732 M. yokogawai for 8 weeks were normal but in a 4-week-old infection the intestinal water content correlated roughly with the number...
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