- RNA polymerase II carboxy-terminal domain with multiple connections
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Cho EJ
- KMID: 1047075
- Exp Mol Med.
- 2007 Jun;39(3):247-254.
The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of... -
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- Increased lysine N-methylation of a 23-kDa protein during hepatic regeneration
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Choi YB, Ko MH, Shin CH, Kim KS, Hong KM, Paik MK, Park DE
- KMID: 1056226
- Exp Mol Med.
- 2005 Jun;37(3):155-160.
The methylation of a 23-kDa nuclear protein increased after partial hepatectomy and methylation returned to basal levels after the initial stage of regeneration. The methylating enzyme was partially purified from... -
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- Increased methylation of the cytosolic 20-kD protein is accompanied by liver regeneration in a hepatectomized rat
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Kwon SY, Kim S, Lee K, Kim TJ, Lee SH, Lee KM, Park GH
- KMID: 755670
- Exp Mol Med.
- 2004 Feb;36(1):85-92.
Arginine methylation has been implicated in the signal transduction pathway leading to cell growth. Here we show that a regenerating rat liver following partial hepatectomy exhibited elevated methyltransferase activity as... -
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- Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae
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He Y, Mei H, Yu H, Sun S, Ni W, Li H
- KMID: 2155359
- Exp Mol Med.
- 2014 May;46(5):e94.
- doi: 10.1038/emm.2014.18
Histone deacetylases are involved in many biological processes and have roles in regulating cell behaviors such as cell cycle entry, cell proliferation and apoptosis. However, the effect of histone deacetylases... -
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- Psammaplin A is a natural prodrug that inhibits class I histone deacetylase
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Kim DH, Shin J, Kwon HJ
- KMID: 1103680
- Exp Mol Med.
- 2007 Feb;39(1):47-55.
Histone deacetylase (HDAC) has been highlighted as one of key players in tumorigenesis and angiogenesis. Recently, several derivatives of psammaplin (Psams) from a marine sponge have been known to inhibit... -
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- Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway
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Kim HR, Kim EJ, Yang SH, Jeong ET, Park C, Lee JH, Youn MJ, So HS, Park R
- KMID: 1115939
- Exp Mol Med.
- 2006 Dec;38(6):616-624.
Trichostatin A (TSA), originally developed as an antifungal agent, is one of potent histone deacetylase (HDAC) inhibitors, which are known to cause growth arrest and apoptosis induction of transformed cells,... -
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- Double Strand Break of DNA in Gastric Adenoma and Adenocarcinoma
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Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES
- KMID: 1775922
- Korean J Gastroenterol.
- 2010 Jan;55(1):19-25.
- doi: 10.4166/kjg.2010.55.1.19
BACKGROUND/AIMS: DNA double strand break (DSB) is one of the critical types of DNA damage. When unrepaired DSB is accumulated in the nucleus of the cells having mutations in such... -
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- The functional role of the CARM1-SNF5 complex and its associated HMT activity in transcriptional activation by thyroid hormone receptor
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Choi HK, Choi KC, Oh SY, Kang HB, Lee YH, Haam S, Ahn YH, Kim KS, Kim K, Yoon HG
- KMID: 756078
- Exp Mol Med.
- 2007 Aug;39(4):544-555.
We have investigated the function and mechanisms of the CARM1-SNF5 complex in T3-dependent transcriptional activation. Using specific small interfering RNAs (siRNA) to knock down coactivators in HeLa alpha2 cells, we... -
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- Integrative epigenomic and genomic analysis of malignant pheochromocytoma
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Sandgren J, Andersson , Rada-Iglesias A, Enroth S, Akerstrom , Dumanski J, Komorowski J, Westin G, Wadelius C
- KMID: 1104209
- Exp Mol Med.
- 2010 Jul;42(7):484-502.
- doi: 10.3858/emm.2010.42.7.050
Epigenomic and genomic changes affect gene expression and contribute to tumor development. The histone modifications trimethylated histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) are epigenetic regulators associated to... -
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