- DNA Double Strand Breaks in Gastric Epithelium with Helicobacter pylori Infection
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Chang YJ, Byun SW, Kim HK, Cho YS, Kim SS, Kim JI, Kim JK, Jung ES
- KMID: 1387335
- Korean J Gastroenterol.
- 2012 Aug;60(2):79-85.
- doi: 10.4166/kjg.2012.60.2.79
BACKGROUND/AIMS: DNA double strand breaks (DSB) is one of the critical types of DNA damage. If unrepaired, DSB is accumulated in the nucleus of cells, the cells become apoptotic or... -
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- Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A
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Tran HT, Kim HN, Lee IK, Nguyen-Pham TN, Ahn JS, Kim YK, Lee JJ, Park KS, Kook H, Kim HJ
- KMID: 1429188
- J Korean Med Sci.
- 2013 Feb;28(2):237-246.
- doi: 10.3346/jkms.2013.28.2.237
SUV39H1 is a histone 3 lysine 9 (H3K9)-specific methyltransferase that is important for heterochromatin formation and the regulation of gene expression. Chaetocin specifically inhibits SUV39H1, resulted in H3K9 methylation reduction... -
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