- Beyond angiogenesis blockade: targeted therapy for advanced cervical cancer
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Eskander R, Tewari KS
- KMID: 2130106
- J Gynecol Oncol.
- 2014 Jul;25(3):249-259.
- doi: 10.3802/jgo.2014.25.3.249
The global burden of advanced stage cervical cancer remains significant, particular in resource poor countries where effective screening programs are absent. Unfortunately, a proportion of patients will be diagnosed with... -
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- Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A
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Tran HT, Kim HN, Lee IK, Nguyen-Pham TN, Ahn JS, Kim YK, Lee JJ, Park KS, Kook H, Kim HJ
- KMID: 1429188
- J Korean Med Sci.
- 2013 Feb;28(2):237-246.
- doi: 10.3346/jkms.2013.28.2.237
SUV39H1 is a histone 3 lysine 9 (H3K9)-specific methyltransferase that is important for heterochromatin formation and the regulation of gene expression. Chaetocin specifically inhibits SUV39H1, resulted in H3K9 methylation reduction... -
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