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Alterations of HLA class I and class II antigen expressions in borderline, invasive and metastatic ovarian cancers

Lee YS, Kim TE, Kim BK, Park YG, Kim GM, Jee SB, Ryu KS, Kim IK, Kim JW

  • KMID: 1093593
  • Exp Mol Med.
  • 2002 Mar;34(1):18-26.
In an effort to understand whether HLA class I and II plays any role in the process of tumorigenesis and metastasis, we have immunohistochemically examined expression of HLA class I...
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Reconstitution of class I MHC molecules expressed in E. coli and complexed with single antigenic peptides

Kim J, Kim MY, Chwae YJ, Park JH

The HLA-Cw3 heavy chain has been expressed at high level as insoluble protein aggregates in E. coli. The protein aggregates dissolved in strong denaturant solution were efficiently reconstituted by...
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HFE gene mutation, C282Y causing hereditary hemochromatosis in Caucasian is extremely rare in Korean population

Lee JY, Yoo KH, Hahn SH

Hereditary hemochromatosis (HFE), which affects 1 in 400 and has an estimated carrier frequency of 1 in 10 individuals in Western population, results in multiple organ damage caused by iron...
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Molecular genetics (HLA) of Behcet's disease

Mizuki N, Inoko H, Ohno S

Behcet's disease (BD) has been known to be strongly associated with the human leukocyte antigen (HLA) B51. This B51 association has been confirmed in many different ethnic groups between the...
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Targeted resequencing of candidate genes reveals novel variants associated with severe Behcet's uveitis

Kim SJ, Lee S, Park C, Seo JS, Kim JI, Yu HG

  • KMID: 2154268
  • Exp Mol Med.
  • 2013 Oct;45(10):e49.
Behcet's disease (BD) is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent uveitis, oral and genital ulcers and skin lesions. To identify some pathogenic variants associated with...
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