- Altered remodeling of nucleolar machineries in cultured hepatocytes treated with thioacetamide
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Jeong JS, Han SY, Kim YH, Choi YC
- KMID: 1066498
- J Korean Med Sci.
- 2001 Feb;16(1):75-82.
- doi: 10.3346/jkms.2001.16.1.75
Thioacetamide (TA) is converted into a hyperacetylating agent which causes hepatic necrosis, regeneration, cirrhosis and cancerous transformation. One of the most characteristic toxicities of TA in rat is observed with... -
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- N-acetylcysteine protects against cadmium-induced oxidative stress in rat hepatocytes
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Wang J, Zhu H, Liu X, Liu Z
- KMID: 2070234
- J Vet Sci.
- 2014 Dec;15(4):485-493.
- doi: 10.4142/jvs.2014.15.4.485
Cadmium (Cd) is a well-known hepatotoxic environmental pollutant. We used rat hepatocytes as a model to study oxidative damage induced by Cd, effects on the antioxidant systems, and the role... -
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- Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis
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Yoon YS, Ryu D, Lee MW, Hong S, Koo SH
- KMID: 1119323
- Exp Mol Med.
- 2009 Aug;41(8):577-583.
- doi: 10.3858/emm.2009.41.8.063
During fasting periods, hepatic glucose production is enhanced by glucagon to provide fuels for other organs. This process is mediated via cAMP-dependent induction of the CREB regulated transcriptional coactivator (CRTC)... -
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- The nuclear 16-kD protein methylation increases in the early period of liver regeneration in a hepatectomized rat
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Lee K, Lee KM, Kim TJ, Han JS, Kim MK, Hong YS, Park GH, Lee KW
- KMID: 1103324
- Exp Mol Med.
- 2004 Dec;36(6):563-571.
Methylation events play a critical role in various cellular processes including regulation of gene transcription and proliferation. We observed that methyltransferase activity underwent time-dependent changes in the cytosol of the... -
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- Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition
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Li TZ, Kim SM, Hur W, Choi JE, Kim JH, Hong SW, Lee EB, Lee JH, Yoon SK
- KMID: 2412161
- Gut Liver.
- 2017 Jan;11(1):102-111.
- doi: 10.5009/gnl15566
BACKGROUND/AIMS: The role of Elk-3 in the epithelial-mesenchymal transition (EMT) during liver fibrogenesis remains unclear. Here, we determined the expression of Elk-3 in in vitro and in vivo models and... -
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- Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1
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Jung YA, Kim HK, Bae KH, Seo HY, Kim HS, Jang BK, Jung GS, Lee IK, Kim MK, Park KG
- KMID: 2155338
- Exp Mol Med.
- 2014 Jan;46(1):e73.
- doi: 10.1038/emm.2013.143
Hepatic steatosis is common in obese individuals with hyperinsulinemia and is an important hepatic manifestation of metabolic syndrome. Sterol regulatory binding protein-1c (SREBP-1c) is a master regulator of lipogenic gene... -
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- Effect of diet on aflatoxin B1-DNA binding and aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci in the rat
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Kimura M, Lehmann K, Gopalan-Kriczky P, Lotlikar P
- KMID: 1094079
- Exp Mol Med.
- 2004 Aug;36(4):351-357.
Effects of diets on hepatic aflatoxin B1 (AFB1)- DNA binding and AFB1-induced glutathione S- transferase placental (GST-P) form positive hepatic foci have been examined in young male Fischer rats. Animals... -
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