- Hepatitis C Virus and Antiviral Drug Resistance
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Kim S, Han KH, Ahn SH
- KMID: 2412093
- Gut Liver.
- 2016 Nov;10(6):890-895.
- doi: 10.5009/gnl15573
Since its discovery in 1989, hepatitis C virus (HCV) has been intensively investigated to understand its biology and develop effective antiviral therapies. The efforts of the previous 25 years have... -
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- Effectiveness and Complications of Combination Therapy with Interferon Alpha and Ribavirin in Patients with Chronic Hepatitis C
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Hwang SY, Lee HJ, Park KT, Kim KY, Lee SM, Park CW, Kim TO, Kim GH, Heo J, Kang DH, Song GA, Cho M, Cho BM
- KMID: 782839
- Korean J Gastroenterol.
- 2007 Mar;49(3):166-172.
BACKGROUND/AIMS: The effectiveness of combination therapy with conventional or pegylated interferon alpha and ribavirin in patients with chronic hepatitis C is well understood. However, the profound investigation about complications of... -
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- Secreted Phosphoprotein 1 Promoter Genetic Variants Are Associated with the Response to Pegylated Interferon alpha Plus Ribavirin Combination Therapy in Egyptian Patients with Chronic Hepatitis C Virus Infection
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Ali FT, Ali MA, Elgizawy M, Elsawy AM
- KMID: 2160636
- Gut Liver.
- 2015 Jul;9(4):516-524.
- doi: 10.5009/gnl14162
BACKGROUND/AIMS: The T-helper 1 (TH1) immune reaction is essential for the eradication of hepatitis C virus (HCV) during pegylated interferon alpha (PEG-IFN-alpha)- and ribavirin (RBV)-based therapy in chronic HCV patients.... -
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- Peginterferon Alfa-2a plus Ribavirin for Initial Treatment of Chronic Hepatitis C in Korea
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Lee H, Choi MS, Paik SW, Kim JH, Kim DY, Lee JH, Koh KC, Yoo BC, Rhee JC, Song SM
- KMID: 760628
- Korean J Hepatol.
- 2006 Mar;12(1):31-40.
BACKGROUND/AIMS: Combination therapy with peginterferon and ribavirin is a standard therapy for western patients with chronic hepatitis C; however, its efficacy remains unclear in East Asian patients. We evaluated... -
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- A reduced dose of ribavirin does not influence the virologic response during pegylated interferon alpha-2b and ribavirin combination therapy in patients with genotype 1 chronic hepatitis C
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You BC, Kim YS, Kim HI, Kim SH, Park SS, Seo YR, Kim SG, Lee SW, Kim HS, Jeong SW, Jang JY, Kim BS
- KMID: 1392906
- Clin Mol Hepatol.
- 2012 Sep;18(3):272-278.
- doi: 10.3350/cmh.2012.18.3.272
BACKGROUND/AIMS: When combined with pegylated interferon alpha-2b (Peg-IFN alpha-2b) for the treatment of genotype 1 chronic hepatitis C (CHC) in Korea, the current guideline for the initial ribavirin (RBV) dose... -
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- Assessment of the Efficacy of Reducing Peginterferon Alfa-2a and Ribavirin Dose on Virologic Response in Koreans with Chronic Hepatitis C
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Kwon JH, Bae SH, Choi JY, Yoon SK, Byun KS, Paik SW, Lim YS, Lee HC, Han KH, Lee KS
- KMID: 1717943
- Korean J Intern Med.
- 2009 Sep;24(3):203-211.
- doi: 10.3904/kjim.2009.24.3.203
BACKGROUND/AIMS: The virologic response of Koreans to combination therapy for chronic hepatitis C is similar to westerns; however, dose modification occurs more frequently in Koreans. We evaluated the rates of... -
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- Mutations within the interferon sensitivity determining region in Korean patients infected with hepatitis C virus genotype 1b
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Jin YJ, Park YK, Yun GJ, Lee HC, Jeong SH, Kim GM, Lim YS, Chung YH, Lee YS, Suh DJ
- KMID: 1792594
- Korean J Hepatol.
- 2010 Jun;16(2):158-167.
- doi: 10.3350/kjhep.2010.16.2.158
BACKGROUND/AIMS: The treatment response to interferon could differ with mutations in the interferon-sensitivity-determining region (ISDR) in patients infected with hepatitis C virus (HCV) genotype-1b (HCV-Ib). We examined the pattern of... -
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