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Clinical analysis of hospitalized patients with hemophilia A: single-hemophilia treatment center experience in Korea over 10 years

Kim JY, Park SJ, You CW

Background: There is lack of data on admitted hemophilia patients in Korea. For this reason, this study was intended to analyze the hospitalization data of hemophilia patients in a regional...
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An anesthetic management of head and neck cancer reconstructive surgery in a patient having hemophilia A: a case report

Ryoo SH, Kwon D, Lee JH, Seo KS, Kim HJ, Karm MH

Hemophilia A is a hemorrhagic disease caused by coagulation factor VIII deficiency. In head and neck cancer surgery, especially during a reconstructive one, complications can occur. These include hematomas due...
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Safety and effectiveness of Rixubis in patients with hemophilia B: a real-world, prospective, postmarketing surveillance study in South Korea

Choi EJ, Hwang Tj, Choi YM, Kim HC, Yoo MC, Song H, Badejo K

Background Rixubis (recombinant factor IX, nonacog gamma) is indicated for the control and prevention of bleeding episodes, perioperative management, and routine prophylaxis in hemophilia B patients. This real-world, postmarketing surveillance study...
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Perioperative Management and Outcomes in Children with Hereditary Bleeding Disorder: a Retrospective Review at a Single Hemophilia Treatment Center

Chon HN, Cho JH, Park YS

Background: Establishing hemostasis for surgical procedures in children with hereditary bleeding disorders is challenging. We evaluated the results of surgical procedures in children with hereditary bleeding disorders at our center...
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Acquired Hemophilia A with Gastrointestinal Bleeding

Park N, Jang JS, Cha JH

Peptic ulcer disease is the most common cause of acute gastrointestinal bleeding, followed by variceal bleeding, Mallory–Weiss syndrome, and malignancy. On the contrary, acquired hemophilia A is a very rare...
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The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A

Kim JY, You CW

BACKGROUND: Risk factors for the development of inhibitors in previously untreated patients (PUPs) have been reported; this is not the case in previously treated patients (PTPs) owing to fewer studies....
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Subgroup analysis of a phase 2/3 study of rurioctocog alfa pegol in patients with severe hemophilia A: efficacy and safety in previously treated Korean patients

You CW, Baek HJ, Park SK, Park YS, Shin HJ, Engl W, Tangada S

BACKGROUND: The efficacy and safety of extended half-life, full-length, pegylated recombinant factor VIII rurioctocog alfa pegol [BAX 855, ADYNOVATE (USA)/ADYNOVI (Europe); Baxalta US Inc., a Takeda company, Lexington, MA, USA]...
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The Effectiveness of Interventional Trans-Arterial Embolization to Control Active Bleeding Before Medical Treatment in Patients with Acquired Hemophilia Presenting as Retroperitoneal Hematoma and Hemothorax: A Case Report

Kim DK

The author report a case involving a 60-year-old man with acquired hemophilia who presented with sudden-onset left abdominal pain and exhibited retroperitoneal hematoma and hemothorax. In the long term, the...
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Various Complications after a Vascular Procedure in Patients with Hemophilia

Ha YS, Park YS

Hemophilia, an inherited bleeding disorder, is caused by a deficiency of coagulation factor VIII or IX. Most of patients with hemophilia need vascular procedure, which can lead to complications. Even...
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Acquired Hemophilia in a Patient Presenting with Swollen Left Limb

Kiam GW

Acquired hemophilia is a rare, potentially life-threatening disease that usually remains under-recognized especially in a primary setting; thus, diagnosing this disease is very challenging. Given its prevalence in elderly patients,...
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Hemophilia A in a Female Patient with Recurrent Vitreous Hemorrhage

Kim HJ, Nam MS, Choo HK, Kim SH

PURPOSE: To report a case of recurrent intraocular hemorrhage due to type A hemophilia in a female patient without any previous medical history. CASE SUMMARY: A 51-year-old female patient without any...
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Spontaneous Retroperitoneal Hemorrhage Caused by Idiopathic Acquired Hemophilia A Misdiagnosed as a Delayed Traumatic Hematoma: A Case Report

Kim SH, Park SJ, Park CI, Choi SU, Kim JH

Acquired hemophilia A (AHA) is a rare disease where typically coagulation factor VIII is inhibited by autoantibodies. It occurs in patients with no personal or familial history of bleeding. In...
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A Case of Hemophilia B Diagnosed after Rhinosinus Surgery in 37 Year-Old Patient

Kim HD, Choi IS

Hemophilia is an X-linked recessive disorder, which is classified into hemophilia A, defined by factor VIII deficiency and hemophilia B, defined by factor IX deficiency. The usual clinical presentation is...
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Perioperative Management of Patients with Hemophilia during Spinal Surgery

Kobayashi , Imagama S, Ando K, Ito K, Tsushima M, Morozumi M, Tanaka S, Machino M, Ota K, Nishida Y, Ishiguro N

STUDY DESIGN: Single-center retrospective study. PURPOSE: To optimize the perioperative management of patients with hemophilia who are undergoing spinal surgery. OVERVIEW OF LITERATURE: Hemophilia is a rare disease in which there is...
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Clinical and Radiological Evaluation After Chemical Synovectomy With Rifampicin in Hemophilic Arthropathy: Korean Experience With a 2-Week Interval Protocol

Suh HC, Kim DK, Kang SH, Seo KM, Kim HS, Lee JY, Lee SY, Yoo KY

OBJECTIVE: To assess the clinical outcome of chemical synovectomy with rifampicin in hemophilic arthropathy by using the World Federation of Hemophilia (WFH) scoring system and plain radiograph. METHODS: We performed rifampicin...
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A case report spontaneous spinal epidural hematoma diagnosed in a hemophilic child with neck pain

Lee HJ

Hemophilia is a disease that causes a hemorrhagic tendency due to a congenital deficiency of blood clotting factors. Hemorrhagic arthritis is the most common complication in hemophilia patients, and hemorrhage...
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Septic Arthritis and Infective Endocarditis in an Adolescent Hemophilia B Patient with an Inhibitor and a Central Venous Access Device

Kim J, Park YS

Central venous access devices (CVAD) provide hemophilic patients, particularly children, with prolonged reliable venous access to promote routine factor replacement therapy. However, one of the significant complications of CVAD use...
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Educational Interventions to Enhance Adherence to Prophylactic Treatment in Korean Hemophilia Patients

Na JH, Yoo KY, Kim JY, Park SK, Kim SK, Choi EJ

BACKGROUND: A patient's adherence to prophylactic treatment is one of the most significant factors to achieve desired outcomes, in regards to the quality of life and treatment cost-effectiveness. The aim...
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Progress of Hemophilia A Therapeutics in Korea

Kim DH, Kim SK

Over the past several decades, hemophilia treatment in Korea has progressed dramatically. It has become possible to prevent hemophilia complications by maintenance treatment as well as on-demand treatment with the...
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Global hemostatic assay of different target procoagulant activities of factor VIII and factor IX

Yoo KY, Jung SY, Hwang SH, Lee SM, Park JH, Nam HJ

BACKGROUND: Korean National Health Insurance reimburses factor VIII (FVIII) and factor IX (FIX) clotting factor concentrate (CFC) infusions to discrepant activity levels, allowing elevation of FVIII activity to 60 IU/dL...
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