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Patients With Definite and Inconclusive Evidence of Reflux According to Lyon Consensus Display Similar Motility and Esophagogastric Junction Characteristics

Ribolsi M, Savarino E, Rogers B, Rengarajan A, Coletta MD, Ghisa M, Cicala M, Gyawali CP

  • KMID: 2521157
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):565-573.
  • doi: 10.5056/jnm20158
Background/Aims The role of esophageal high-resolution manometry (HRM) within Lyon consensus phenotypes, especially patients with inconclusive gastroesophageal reflux disease (GERD) evidence, has not been fully investigated. In this multicenter, observational study...
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Efficacy of S-pantoprazole 10 mg in the Symptom Control of Non-erosive Reflux Disease: A Phase III Placebo-controlled Trial

Cho YK, Choi MG, Park H, Kim JW, Lee DH, Ko KH, Kim SG, Jung HY, Hong SJ, Lee YC, Lee SH

  • KMID: 2514680
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):223-230.
  • doi: 10.5056/jnm19053
Background/Aims S-isomer (S) pantoprazole is more bioavailable and less dependent on cytochrome 2C19 than is racemic pantoprazole. We aim to evaluate the efficacy and safety of 10 mg S-pantoprazole for treatment...
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Effects of the Rome IV Criteria to Functional Dyspepsia Symptoms in Saudi Arabia: Epidemiology and Clinical Practice

Zacharakis G, Al-Ghamdi S, AlZahrani J, Almasoud A, Arahmane O, AlShehri A, Alharbi MH, Alsalmi MM, Alotibi SB, Algaradi YA, Alsadiq FN, Nikolaidis P

Background/Aims: Limited data is available in Saudi Arabia (SA) regarding the prevalence of functional dyspepsia (FD) symptoms and its subtypes, as defined by the ROME IV criteria. This study evaluated...
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High-resolution Manometry Determinants of Refractoriness of Reflux Symptoms to Proton Pump Inhibitor Therapy

Ribolsi M, Savarino E, Rogers B, Rengarajan A, Coletta MD, Ghisa M, Cicala M, Gyawali CP

  • KMID: 2507109
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):447-454.
  • doi: 10.5056/jnm19153
Background/Aims Impaired esophageal motility and disrupted esophagogastric junction (EGJ) on high-resolution manometry (HRM) have been associated with increased reflux severity in gastroesophageal reflux disease (GERD) patients. However, there are limited data...
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Measurement of Esophageal Nocturnal Baseline Impedance: A Simplified Method

Hoshikawa , Sawada A, Sonmez S, Nikaki K, Woodland P, Yazaki E, Sifrim D

  • KMID: 2500681
  • J Neurogastroenterol Motil.
  • 2020 Apr;26(2):.
  • doi: 10.5056/jnm19183
Background/Aims Mean nocturnal baseline impedance (MNBI) during multichannel intraluminal impedance pH-monitoring (MII-pH) reflects the status of esophageal mucosal integrity. MNBI is suggested as an adjunctive method to distinguish patients with...
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Phase 4 Study in Patients From Asia With Gastroesophageal Reflux Disease Treated With Dexlansoprazole

Wu JCY, Sheu BS, Wu MS, Lee YC, Choi MG

  • KMID: 2500653
  • J Neurogastroenterol Motil.
  • 2020 Jan;26(1):85-95.
  • doi: 10.5056/jnm19031
Background/Aims Since the use of dexlansoprazole in Asian subjects with gastroesophageal reflux disease (GERD) has not been adequately characterized, this study was conducted to evaluate the efficacy and safety of...
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Role of Esophageal Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Discriminating Chinese Patients With Heartburn

Sun YM, Gao Y, Gao F

  • KMID: 2460480
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):515-520.
  • doi: 10.5056/jnm19056
BACKGROUND/AIMS: Recently, esophageal mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index have been proposed, which can increase the diagnostic role of multichannel intraluminal impedance and pH...
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Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis

Song IJ, Kim HK, Lee NK, Lee SK

PURPOSE: Patients with gastroesophageal reflux disease without esophagitis show varying responses to proton pump inhibitors (PPIs). The aim of this study was to objectively evaluate the effect of a new...
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Current Trends in the Management of Gastroesophageal Reflux Disease

Sandhu DS, Fass R

Gastroesophageal reflux disease (GERD) characterized by heartburn and/or regurgitation symptoms is one of the most common gastrointestinal disorders managed by gastroenterologists and primary care physicians. There has been an increase...
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Reflux Hypersensitivity: A New Functional Esophageal Disorder

Yamasaki T, Fass R

  • KMID: 2395417
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):495-503.
  • doi: 10.5056/jnm17097
Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal disorder, is currently considered as the presence of typical heartburn symptoms in patients with normal upper endoscopy and...
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Understanding the Rome IV: Esophageal Disorders

Park MI

The Rome IV criteria, published in 2016, encompass upper gastrointestinal lesions of functional esophageal disorders and functional gastroduodenal disorders. Functional esophageal disorders include functional chest pain, functional heartburn, reflux hypersensitivity,...
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The Application of the Rome IV Criteria to Functional Esophagogastroduodenal Disorders in Asia

Suzuki H

  • KMID: 2387822
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):325-333.
  • doi: 10.5056/jnm17018
The Rome criteria were amended as Rome IV. For functional esophageal disorders, the exclusion criteria have been more specifically revised based on further understanding of other esophageal disorders, including eosinophilic...
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The Relationship of the Post-reflux Swallow-induced Peristaltic Wave Index and Esophageal Baseline Impedance with Gastroesophageal Reflux Disease Symptoms

Cho YK, Lee JS, Lee TH, Hong SJ, Park SJ, Jeon SR, Kim HG, Kim JO

  • KMID: 2433524
  • J Neurogastroenterol Motil.
  • 2017 Apr;23(2):237-244.
  • doi: 10.5056/jnm16115
BACKGROUND/AIMS: The post-reflux swallow-induced peristaltic wave (PSPW) index and esophageal baseline impedance (BI) are novel impedance parameters used to evaluate esophageal chemical clearance and mucosal integrity. However, their relationship with...
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Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease

Karyampudi A, Ghoshal UC, Singh R, Verma A, Misra A, Saraswat V

  • KMID: 2433521
  • J Neurogastroenterol Motil.
  • 2017 Apr;23(2):208-217.
  • doi: 10.5056/jnm16087
BACKGROUND/AIMS: Though nocturnal acid-breakthrough (NAB) is common in gastroesophageal reflux disease (GERD) patients, its clinical importance results from esophageal acidification, which has been shown to be uncommon. Ilaprazole, a long-acting...
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Is Gastroesophageal Reflux Disease and Achalasia Coincident or Not?

Jung DH, Park H

  • KMID: 2367449
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):5-8.
  • doi: 10.5056/jnm16121
Achalasia and gastroesophageal reflux disease (GERD) are on opposite ends of the spectrum of lower esophageal sphincter dysfunction. Heartburn is the main symptom of GERD. However, heartburn and regurgitation are...
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The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study

Hong SJ, Park SH, Moon JS, Shin WG, Kim JG, Lee YC, Lee DH, Jang JY, Kim JJ, Lee HL, Lee SW, Hwangbo Y, Xu J, Wang B, Xue Z, Liu F, Yuan Y, Leelakusolvong S, Dy F

BACKGROUND/AIMS: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. METHODS: A total of 501 patients with reflux esophagitis were randomized into...
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The Prevalence and Clinical Features of Non-responsive Gastroesophageal Reflux Disease to Practical Proton Pump Inhibitor Dose in Korea: A Multicenter Study

Park HJ, Park SH, Shim KN, Kim YS, Kim HJ, Han JP, Kim YS, Bang BW, Kim GH, Baik GH, Kim HH, Park SY, Kim SS

BACKGROUND/AIMS: In Korea, there are no available multicenter data concerning the prevalence of or diagnostic approaches for non-responsive gastroesophageal reflux disease (GERD) which does not respond to practical dose of...
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Esophageal Submucosal Injection of Capsaicin but Not Acid Induces Symptoms in Normal Subjects

Lee RH, Korsapati , Bhalla V, Varki N, Mittal RK

  • KMID: 2327948
  • J Neurogastroenterol Motil.
  • 2016 Jul;22(3):436-443.
  • doi: 10.5056/jnm15166
BACKGROUND/AIMS: Transient receptor potential vanilloid-1 (TRPV1) is a candidate for mediating acid-induced symptoms in the esophagus. We conducted studies to determine if the presence of acid in the mucosa/submucosa and...
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Underlying Mechanisms and Management of Refractory Gastroesophageal Reflux Disease

Lee KJ

The prevalence of gastroesophageal reflux disease (GERD) in South Korea has increased over the past 10 years. Patients with erosive reflux disease (ERD) shows better response to proton pump inhibitors...
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Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman R, Maradey-Romero C, Gingold-Belfer R, Fass R

  • KMID: 2433470
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):309-319.
  • doi: 10.5056/jnm15105
Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements...
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