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Sesquiterpenoids from the Stem Bark of Aglaia grandis

Harneti D, Permatasari AA, Anisshabira A, Naini AA, N, Mayanti T, Maharani R, Safari A, Hidayat AT, Farabi K, Supratman U, Azmi MN, Shiono Y

Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds’ (1-5) chemical structures were...
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Pseudolaric acid B inhibits PAX2 expression through Wnt signaling and induces BAX expression, therefore promoting apoptosis in HeLa cervical cancer cells

Guan D, Li C, Lv X, Yang Y

OBJECTIVES: Pseudolaric acid B (PAB) has been shown to inhibit the growth of various tumor cells, but the molecular details of its function are still unknown. This study investigated the...
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Effects of genistein on anti-tumor activity of cisplatin in human cervical cancer cell lines

Liu H, Lee G, Lee JI, Ahn TG, Kim SA

OBJECTIVE: To investigate the effect of genistein on the anticancer effects of chemotherapeutic agents, we examined the effect of a genistein and cisplatin combination on CaSki human cervical cancer cells. METHODS:...
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In Vitro and in Vivo Effects of Nitrofurantoin on Experimental Toxoplasmosis

Yeo SJ, Jin C, Kim S, Park H

Toxoplasma gondii is an important opportunistic pathogen that causes toxoplasmosis, which has very few therapeutic treatment options. The most effective therapy is a combination of pyrimethamine and sulfadiazine; however, their...
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Analysis of lysosomal membrane proteins exposed to melanin in HeLa cells

Bang SH, Park DJ, Kim YH, Min J

OBJECTIVES: There have been developed to use targeting ability for antimicrobial, anticancerous, gene therapy and cosmetics through analysis of various membrane proteins isolated from cell organelles. METHODS: It was examined about...
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Measurement of apoptosis using M30 in culture media of cell lines treated with anti-cancer agents

Park SH, Kwack HS, Ryu KS, Lee Y, Han KT

OBJECTIVE: We investigated a possible use of the induced apoptosis as a biomarker in the cells and their media treated with commonly used anti-cancer agents in gynecologic malignancies. METHODS: After treatments...
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Effects of Artemisia Capillaris Thunberg on Apoptosis in HeLa Cells

Lee HJ, Kim KH, Park JK, Hwang EH

  • KMID: 2261192
  • Korean J Nutr.
  • 2008 Jan;41(1):22-30.
This study analyzes the apoptosis of HeLa cells to see if we can use the Artemisia capillaris Thunberg for the prevention of chronic degenerative diseases. We used the HeLa cells...
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Treatment with sodium butyrate and rapamycin inhibit growth of human cervical cancer cells

Jeon YJ, Cho CH, Shin SJ, Kwon SH, Cha SD

  • KMID: 2244544
  • Korean J Gynecol Oncol.
  • 2007 Sep;18(3):165-171.
OBJECTIVE: To evaluate whether mTOR inhibition by rapamycin can enhance the inhibitory effect of sodium butyrate, a histone deacetylase (HDAC) inhibitor on human cervical cancer cell line HeLa. METHODS: Cervical...
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Adhesion of Weissella cibaria to the Epithelial Cells and Factors Affecting its Adhesion

Kang MS, Piao MS, Shin BA, Lee HC, Oh JS

We evaluated the ability of lactic acid bacteria, Weissella cibaria, isolated from the oral cavity to adhere to epithelial cells. W. cibaria efficiently adhered to KB cells and HeLa cells....
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Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death

Gong X, Wang M, Tashiro SI, Onodera S, Ikejima T

  • KMID: 1110127
  • Exp Mol Med.
  • 2006 Aug;38(4):428-434.
A terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay was used to determine that apoptosis causes HeLa cell death induced by pseudolaric acid B. The c-Jun N-terminal kinase (JNK) inhibitor...
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Overexpression of the Fanconi Anemia A Gene in Hela and MCF10A Cells

Park WH

BACKGROUND: Fanconi Anemia (FA) is an autosomal recessive inherited disease, which is characterized by developmental abnormalities, progressive bone marrow failure and a predisposition to cancer. The phenotypes of FA cells...
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The Effect of Green Tea Extract on Cisplatin in Cervical Cancer Cell Lines

Ahn TG, Kim DW, Lee BR, Han SJ

  • KMID: 2013153
  • Korean J Obstet Gynecol.
  • 2006 Mar;49(3):592-598.
OBJECTIVE: Green tea polyphenol (GTP) has been shown to have anti-tumor properties in a wide variety of experimental systems. In this study, we evaluated the effects of GTP on the...
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The Modulation of Radiosensitivity by Combined Treatment of Selective COX-2 Inhibitor, NS 398 and EGF Receptor Blocker AG 1478 in HeLa Cell Line

Youn SM, Oh YK, Kim JH, Park MJ, Seong IO, Kang K, Chai G

  • KMID: 2323842
  • J Korean Soc Ther Radiol Oncol.
  • 2005 Mar;23(1):51-60.
PURPOSE: Selective inhibition of multiple molecular targets may improve the antitumor activity of radiation. Two specific inhibitors of selective cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) were combined with...
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Identification of Differentially Expressed Radiation-induced Genes in Cervix Carcinoma Cells Using Suppression Subtractive Hybridization

Kim JS, Lee YS, Lee JH, Lee WH, Seo EY, Cho MJ

  • KMID: 2323841
  • J Korean Soc Ther Radiol Oncol.
  • 2005 Mar;23(1):43-50.
PURPOSE: A number of genes and their products are induced early or late following exposure of cells to ionizing radiation. These radiation-induced genes have various effects on irradiated cells and...
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Detection of RTP801, a Gene That is Differentially Expressed in Irradiated HeLa Cells

Lee YS, Cho MJ, Lee JH, Lee WH, Kim JS

  • KMID: 2166141
  • Cancer Res Treat.
  • 2004 Aug;36(4):263-270.
PURPOSE: To quantify the effects of irradiation on the expression levels of a differentially expressed gene, RTP801, in HeLa cells. MATERIALS AND METHODS: Total RNA was isolated from irradiated and...
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Involvement of Oxidative Stress in Cisplatin-Induced Apoptosis in HeLa Cells

Ko KH, Kim SH, Cho HJ, Oh SH, Kim HG, Park RG

  • KMID: 1925291
  • Korean J Obstet Gynecol.
  • 2003 Dec;46(12):2410-2416.
OBJECTIVE: To determine whether oxidants are formed as part of the cisplatin-induced apoptotic process, intracellular markers of oxidative stress were examined. METHODS: Apoptotic death of HeLa cells by cisplatin was confirmed...
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The Study of the Cytotoxic Mechanism of Cisplatin in HeLa Cells

Choi JH, Cho H, Lee SY, Oh SH, Kim HG, Park RG

  • KMID: 2076939
  • Korean J Obstet Gynecol.
  • 2003 Oct;46(10):1989-1998.
Cis-diamminedichloroplatinum II (cisplatin) has been reported to induce cell death. However, the mechanism by which cisplatin is induced the apoptosis of cancer cells is still unclear. To evaluate the mechanistic...
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The Mechanism of Intracellular Signal Pathway that Baicalin Hydrate Elevate Chemotherapeutic Response of Cervical Carcinoma

Kim BR, Kim IS, Ko KH, Lee JJ, Kim HG, Park RG

  • KMID: 2076936
  • Korean J Obstet Gynecol.
  • 2003 Oct;46(10):1965-1974.
Baicalin is flavonoid and major component of PC-SPES. Flavonoids including baicalin have been reported to not only function as anti-oxidant but also cause cytotoxic effect. Baicalin hydrate has been reported...
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Cell Cycle and Gene Expression of Adriamycin-Induced Apoptosis in Human Cervical Carcinoma HeLa cells

Kim JH, Lee TH, Hwangbo HJ, Lee YH, Koh MW

  • KMID: 2262464
  • Korean J Obstet Gynecol.
  • 2001 Dec;44(12):2194-2200.
OBJECTIVE: This work was demonstrated the induction of apoptosis in response to adriamycin, we checked the cell cycle of adriamycin-induced apoptosis and to investigate whether differential expression is associated with...
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Chromatin Pattern-Dependent mRNA Synthesis in HeLa Cells and HeLa Tumors

Lee JH, Kang MW, Choi C, Juhng SW

  • KMID: 2172398
  • Chonnam Med J.
  • 2001 Dec;37(4):351-356.
Malignant cell nuclei, in general, have increased amount of heterochromatin and decreased electron density of euchromatin, making the chromatin pattern coarser than that of benign cell nuclei. Chromatin pattern in...
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