- Emotional Stress Facilitates Micturition Reflex: Possible Inhibition by an αâ‚-Adrenoceptor Blocker in the Conscious and Anesthetized State
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Hattori T, Sugaya K, Nishijima , Kadekawa K, Ueda T, Yamamoto H
- KMID: 2452557
- Int Neurourol J.
- 2019 Jun;23(2):100-108.
- doi: 10.5213/inj.1836284.142
PURPOSE: To test the hypothesis that naftopidil prolongs intercontraction intervals in rats undergoing chronic stress as observed in previous animal models, voiding behavior and bladder function were measured and analyzed. METHODS:... -
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- Ketanserin and Naftopidil Enhance the Potentiating Effect of Alpha-Methyl-Serotonin on the Neurally-Induced Contraction of Human Isolated Urinary Bladder Muscle Strips
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Hattori T, Lluel P, Rouget C, Rekik M, Yoshiyama
- KMID: 2375590
- Int Neurourol J.
- 2017 Mar;21(1):20-28.
- doi: 10.5213/inj.1732758.379
PURPOSE: The aim of this study was to assess the potential involvement of a specific subtype of 5-hydroxytryptamine (5-HT), 5HT(2) receptors in neurally-induced contractions of the human detrusor. METHODS: Contractile responses... -
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- In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats
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Hattori T, Sugaya K, Nishijima , Kadekawa K, Ueda T, Yamamoto H
- KMID: 2468713
- Int Neurourol J.
- 2019 Dec;23(4):277-286.
- doi: 10.5213/inj.1938102.051
PURPOSE: Alpha-1-adrenoceptor blockers (e.g., naftopidil) are prescribed for the treatment of male lower urinary tract symptoms. Although the mechanism of action of naftopidil has been studied in various organs, that... -
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- Basophil Activation Test Based on CD203c Expression in the Diagnosis of Fish Allergy
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Imakiire R, Fujisawa T, Nagao M, Tokuda R, Hattori T, Kainuma K, Kawano Y
- KMID: 2500744
- Allergy Asthma Immunol Res.
- 2020 Jul;12(4):641-652.
- doi: 10.4168/aair.2020.12.4.641
Purpose: The basophil activation test (BAT) has been reported to be useful for the diagnosis of various food allergies, such as allergy to peanut, but not to fish. This study... -
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- Effect of Alpha 1-Adrnoceptor Antagonists on Postsynaptic Sensitivity in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats Using Slice Patch-Clamp Technique for mEPSC
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Uta D, Hattori T, Yoshimura M
- KMID: 2503371
- Int Neurourol J.
- 2020 Jun;24(2):135-143.
- doi: 10.5213/inj.1938250.125
Purpose: Alpha1-adrenoceptors participate in improving storage symptoms of male lower urinary tract symptoms (LUTS). However, the mechanism of action of these compounds remains unclear. To clarify the mechanism of the... -
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- Characterization on Responsiveness of Excitatory Synaptic Transmissions to α1-Adrenoceptor Blockers in Substantia Gelatinosa Neurons Isolated From Lumbo-Sacral Level in Rat Spinal Cords
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Uta D, Hattori T, Yoshimura
- KMID: 2446742
- Int Neurourol J.
- 2019 Mar;23(1):13-21.
- doi: 10.5213/inj.1938056.028
PURPOSE: The aim of this study was to characterize the responsiveness of miniature excitatory postsynaptic currents (mEPSCs) to α1-adrenoceptor blockers in substantia gelatinosa (SG) neurons from the spinal cord to... -
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- Differential Effects of Alpha 1-Adrenoceptor Antagonists on the Postsynaptic Sensitivity: Using Slice Patch-Clamp Technique for Inhibitory Postsynaptic Current in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats
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Uta D, Hattori T, Yoshimura M
- KMID: 2503370
- Int Neurourol J.
- 2020 Jun;24(2):127-134.
- doi: 10.5213/inj.1938248.124
Purpose: Alpha1-adrenoceptors participate in improving storage symptoms of male lower urinary tract symptoms. However, the mechanism of action of these compounds remains unclear. The goal of the present study was... -
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- Effects of High Concentrations of Naftopidil on Dorsal Root-Evoked Excitatory Synaptic Transmissions in Substantia Gelatinosa Neurons In Vitro
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Uta D, Hattori T, Yoshimura
- KMID: 2431866
- Int Neurourol J.
- 2018 Dec;22(4):252-259.
- doi: 10.5213/inj.1836146.073
PURPOSE: Naftopidil ((±)-1-[4-(2-methoxyphenyl) piperazinyl]-3-(1-naphthyloxy) propan-2-ol) is prescribed in several Asian countries for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Previous animal experiments showed that intrathecal injection of naftopidil... -
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